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Chlorobutanol

Name: Chlorobutanol
Brand: TargetMol
SKU: T0901
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0901Cas No. 57-15-8

Alias YM-57158, Chlortran, Chloretone, Chloreton, Chlorbutol

Chlorobutanol (Chlortran) is a chemical preservative, sedative hypnotic and weak local anaesthetic. It has Antibacterial and Antifungal properties. Chlorobutanol is typically used at a concentration of 0.5% where it lends long-term stability to multi-ingredient formulations.

Chlorobutanol

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Catalog No. T0901Alias YM-57158, Chlortran, Chloretone, Chloreton, ChlorbutolCas No. 57-15-8

Pack Size	Price	USA Warehouse	Global Warehouse
2 g	$30	In Stock	In Stock
5 g	$40	-	In Stock
10 g	$56	-	In Stock
25 g	$81	-	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:≥98%

Appearance:Solid

Color:White

Resource Download

COA HNMR

Product Introduction

Chlorobutanol AI Summary

Chlorobutanol displays a range of bioactivities across various biological targets. It notably inhibits the interaction between the Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 with a potency of 112,201.8 nM, as well as inhibiting GCN5L2, Histone Lysine Methyltransferase G9a, and human tyrosyl-DNA phosphodiesterase 1, with varying potencies from 17,782.8 nM to 39,810.7 nM. Additionally, it acts as a delayed death inhibitor of the malarial parasite plastid within a potency range of 1,694.4 nM to 2,685.5 nM and blocks entry of the Ebola Virus with potencies between 1,258.9 nM and 39,810.7 nM under different conditions. Chlorobutanol also exhibits antiviral properties against SARS-CoV-2, inhibiting cytotoxicity in Caco-2 cells at 10 µM after 48 hours and showing 36.32% inhibition of the SARS-CoV-2 3CL-Pro protease at a 20 µM concentration. However, its inhibition of SARS-CoV-2 induced cytotoxicity in VERO-6 cells at 10 µM is quite minimal, with a 0.16% response. Furthermore, it inhibits human HDAC6 enzyme activity with -48.24% inhibition using a commercial peptide substrate and -3.96% using a custom peptide substrate. In other assays, compound 863857 generally did not show significant activity (AC50 > 10,000.0 nM) against the tested targets, indicating varied efficacy depending on the context..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Chlorobutanol (Chlortran) is a chemical preservative, sedative hypnotic and weak local anaesthetic. It has Antibacterial and Antifungal properties. Chlorobutanol is typically used at a concentration of 0.5% where it lends long-term stability to multi-ingredient formulations.
Synonyms	YM-57158, Chlortran, Chloretone, Chloreton, Chlorbutol

Chemical Properties

Molecular Weight	177.46
Formula	C₄H₇Cl₃O
Cas No.	57-15-8
Smiles	CC(C)(O)C(Cl)(Cl)Cl
Relative Density.	1.3170 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (338.1 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (11.27 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.6351 mL	28.1754 mL	56.3507 mL	281.7536 mL
5 mM	1.1270 mL	5.6351 mL	11.2701 mL	56.3507 mL
10 mM	0.5635 mL	2.8175 mL	5.6351 mL	28.1754 mL
20 mM	0.2818 mL	1.4088 mL	2.8175 mL	14.0877 mL
50 mM	0.1127 mL	0.5635 mL	1.1270 mL	5.6351 mL
100 mM	0.0564 mL	0.2818 mL	0.5635 mL	2.8175 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc