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Anti-SARS-CoV-2 (2019-nCoV) Spike S1 Antibody (3Z498)
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Catalog No. TMAB-12537
Anti-SARS-CoV-2 (2019-nCoV) Spike S1 Antibody (3Z498) is a Mouse antibody targeting SARS-CoV-2 (2019-nCoV) Spike S1. Anti-SARS-CoV-2 (2019-nCoV) Spike S1 Antibody (3Z498) can be used in WB.
Anti-SARS-CoV-2 (2019-nCoV) Spike S1 Antibody (3Z498)
Anti-SARS-CoV-2 (2019-nCoV) Spike S1 Antibody (3Z498)
😃Good
Catalog No. TMAB-12537
Anti-SARS-CoV-2 (2019-nCoV) Spike S1 Antibody (3Z498) is a Mouse antibody targeting SARS-CoV-2 (2019-nCoV) Spike S1. Anti-SARS-CoV-2 (2019-nCoV) Spike S1 Antibody (3Z498) can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 100 μg | $681 | 7-10 days | 7-10 days | |
| 200 μg | $1,057 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-SARS-CoV-2 (2019-nCoV) Spike S1 Antibody (3Z498) is a Mouse antibody targeting SARS-CoV-2 (2019-nCoV) Spike S1. Anti-SARS-CoV-2 (2019-nCoV) Spike S1 Antibody (3Z498) can be used in WB. |
| Ig Type | IgG1 |
| Clone | 3Z498 |
| Reactivity | SARS-CoV-2 |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Subcellular Localization | Virion membrane ; Single-pass type I membrane protein ; Host endoplasmic reticulum-Golgi intermediate compartment membrane ; Single-pass type I membrane protein ; Host cell membrane ; Single-pass type I membrane protein ;Note: Accumulates in the endoplasmic reticulum-Golgi intermediate compartment, where it participates in virus particle assembly. Colocalizes with S in the host endoplasmic reticulum-Golgi intermediate compartment. Some S oligomers are transported to the host plasma membrane, where they may mediate cell-cell fusion. |
| Tissue Specificity | The cytoplasmic Cys-rich domain is palmitoylated. Spike glycoprotein is digested within host endosomes.Specific enzymatic cleavages in vivo yield mature proteins. The precurssor is processed into S1 and S2 by host cell furin or another cellular protease to yield the mature S1 and S2 proteins (PubMed:32155444). Additionally, a second cleavage leads to the release of a fusion peptide after viral attachment to host cell receptor (By similarity). The presence of a furin polybasic cleavage site sets SARS-CoV-2 S apart from SARS-CoV S that possesses a monobasic S1/S2 cleavage site processed upon entry of target cells (PubMed:32155444).Highly decorated by heterogeneous N-linked glycans protruding from the trimer surface. |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M PBS (pH7.4). |
| Concentration | Lot Dependent |
| Research Background | The SARS-CoV-2 spike (S) protein is the target of vaccine design efforts to end the COVID-19 pandemic. Despite a low mutation rate, isolates with the D614G substitution in the S protein appeared early during the pandemic, and are now the dominant form worldwide. Here, we analyze the D614G mutation in the context of a soluble S ectodomain construct. |
| Immunogen | Recombinant Protein: SARS-CoV-2 Spike S1 Protein |
| Gene Name | S |
| Protein Name | Spike glycoprotein |
| Function | attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes. |
| Molecular Weight | Theoretical: 140 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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