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β-Endorphin (1-27) (human) acetate

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Catalog No. T38193L
Alias β-Endorphin (1-27) (human) acetate(76622-84-9 Free base)

β-Endorphin (1-27) (human) acetate, existing in the hypophysis cerebri and hypothalamus, exhibits antinociception activity. β-Endorphin (1-27) (human) acetate is an agonist of opioid receptor, showing preferred affinity for μ-opioid receptor and δ-opioid

β-Endorphin (1-27) (human) acetate
Other Forms of β-Endorphin (1-27) (human) acetate:

β-Endorphin (1-27) (human) acetate

😃Good
Purity: 96.52%
Catalog No. T38193LAlias β-Endorphin (1-27) (human) acetate(76622-84-9 Free base)
β-Endorphin (1-27) (human) acetate, existing in the hypophysis cerebri and hypothalamus, exhibits antinociception activity. β-Endorphin (1-27) (human) acetate is an agonist of opioid receptor, showing preferred affinity for μ-opioid receptor and δ-opioid
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$82In StockIn Stock
5 mg$183In StockIn Stock
10 mg$272In StockIn Stock
25 mg$413In StockIn Stock
50 mg$580In StockIn Stock
100 mg$777-In Stock
200 mg$1,030-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:96.52%
Appearance:Solid
Color:White
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COA MS HPLC

Product Introduction

Bioactivity
Description
β-Endorphin (1-27) (human) acetate, existing in the hypophysis cerebri and hypothalamus, exhibits antinociception activity. β-Endorphin (1-27) (human) acetate is an agonist of opioid receptor, showing preferred affinity for μ-opioid receptor and δ-opioid
In vitro
β-Endorphin (1-27) (human) acetate inhibits the conduction of pain and agitation of nociceptors to exert an analgesic effect. β-Endorphin (1-27) (human) acetate combines together with the opioid receptors in hyperalgesia. β-Endorphin (1-27) (human) acetate suppresses the release of substance P at the level of spinal cord and blocks the conduction of pain on the primary sensory neurons. β-Endorphin (1-27) (human) acetate activates the endogenous analgesia system located in the CNS[1].
Synonymsβ-Endorphin (1-27) (human) acetate(76622-84-9 Free base)
Chemical Properties
Molecular Weight3082.52
FormulaC141H221N33O42S
SmilesCCC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C1CCCN1C(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(CNC(CNC(C(N)CC2=CC=C(O)C=C2)=O)=O)=O)CC3=CC=CC=C3)=O)CCSC)=O)C(O)C)=O)CO)=O)CCC(O)=O)=O)CCCCN)=O)CO)=O)CCC(N)=O)=O)C(O)C)=O)=O)CC(C)C)=O)C(C)C)=O)C(O)C)=O)CC(C)C)=O)CC4=CC=CC=C4)=O)CCCCN)=O)CC(N)=O)=O)C)=O)C(NC(C(NC(C(NC(C(NC(C(NC(C(O)=O)CC5=CC=C(O)C=C5)=O)C)=O)CC(N)=O)=O)CCCCN)=O)C(CC)C)=O)C.CC(O)=O
SequenceDL-Tyr-Gly-Gly-DL-Phe-DL-Met-DL-xiThr-DL-Ser-DL-Glu-DL-Lys-DL-Ser-DL-Gln-DL-xiThr-DL-Pro-DL-Leu-DL-Val-DL-xiThr-DL-Leu-DL-Phe-DL-Lys-DL-Asn-DL-Ala-DL-xiIle-DL-xiIle-DL-Lys-DL-Asn-DL-Ala-DL-Tyr
Sequence ShortYGGFMXSEKSQXPLVXLFKNAXXKNAY
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
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Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

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All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
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Keywords

μ-opioid receptorδ-opioid receptorβEndorphin (127) (human) acetateβ-Endorphin acetate(76622-84-9 Free base)β-Endorphin Acetateβ-Endorphinβ Endorphin (1 27) (human) acetateOpioidReceptorOpioid Receptorbeta-Endorphin acetate(76622-84-9 Free base)beta-Endorphin Acetatebeta-Endorphinb-Endorphin acetate(76622-84-9 Free base)b-Endorphin Acetateb-Endorphin
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