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Anti-VLDLR Antibody (8E223)
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Catalog No. TMAY-01597
Alias VLDLRCH, very low density lipoprotein receptor, CHRMQ1, CARMQ1, CAMRQ1
Anti-VLDLR Antibody (8E223) is a Rabbit antibody targeting VLDLR. Anti-VLDLR Antibody (8E223) can be used in ELISA.
Anti-VLDLR Antibody (8E223)
Anti-VLDLR Antibody (8E223)
😃Good
Catalog No. TMAY-01597Alias VLDLRCH, very low density lipoprotein receptor, CHRMQ1, CARMQ1, CAMRQ1
Anti-VLDLR Antibody (8E223) is a Rabbit antibody targeting VLDLR. Anti-VLDLR Antibody (8E223) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $269 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-VLDLR Antibody (8E223) is a Rabbit antibody targeting VLDLR. Anti-VLDLR Antibody (8E223) can be used in ELISA. |
| Alias | VLDLRCH, very low density lipoprotein receptor, CHRMQ1, CARMQ1, CAMRQ1 |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 8E223 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human VLDLR (rh VLDLR; TMPY-01085; NP_003374.3; Met1-Ser797). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | The very low density lipoprotein receptor, known as VLDLR, is a single-pass type 1 integral membrance protein and a member of the LDL receptor family. This receptor family includes LDL receptor, LRP, megalin, VLDLR and ApoER2, and is characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar sdomain. VLDLR contains 3 EGF-like domains, 8 LDL-receptor class A domains, as well as 6 LDL-receptor class B repeats, and is abundant in heart, skeletal muscle, also ovary and kidney, but not in liver. VLDLR binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. VLDLR mediates the phosphorylation of mDab1 (mammalian disabled protein) via binding to Reelin, and induces the modulation of Tau phosphorylation. This pathway regulates the migration of neurons along with the radial glial fiber network during brain development. Defects of VLDLR may be the cause of VLDLR-associated cerebellar hypoplasia (VLDLRCH), a syndrome characterized by moderate-to-profound mental retardation, delayed ambulation, and predominantly truncal ataxia. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human VLDLR protein (TMPY-01085) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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