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(S)-3,5-DHPG

Name: (S)-3,5-DHPG
Brand: TargetMol
SKU: T23289
Rating: 4.5 (1 reviews)

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Catalog No. T23289Cas No. 162870-29-3

(S)-3,5-DHPG is a weak but selective agonist of group I metabotropic glutamate receptors with Ki values of 0.9 μM for mGluR1a and 3.9 μM for mGluR5a. (S)-3,5-DHPG demonstrates anxiolytic activity in hypoxia-exposed rats, supporting its application in neuropharmacological studies of glutamatergic signaling, stress responses, and anxiety-related behaviors.

(S)-3,5-DHPG

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Catalog No. T23289Cas No. 162870-29-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$143	35 days	35 days
5 mg	$315	35 days	35 days
10 mg	$550	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	(S)-3,5-DHPG is a weak but selective agonist of group I metabotropic glutamate receptors with Ki values of 0.9 μM for mGluR1a and 3.9 μM for mGluR5a. (S)-3,5-DHPG demonstrates anxiolytic activity in hypoxia-exposed rats, supporting its application in neuropharmacological studies of glutamatergic signaling, stress responses, and anxiety-related behaviors.
Targets&IC50	mGluR4:> 100 μM (EC50), mGluR1a (rat):0.9 μM (Ki)
In vitro	In receptor binding studies, (S)-3,5-DHPG targeted Group I mGlu binding domains with affinity for rat mGluR1a (Ki = 0.9 μM) and mGluR5a (Ki = 3.9 μM). Selectivity assays confirmed it remained inactive at Group III receptors, showing an EC50 > 100 μM for stimulating phosphatidylinositol accumulation in mGluR4-expressing cells [1].
In vivo	In male Wistar rats undergoing experimental hypoxia, intracerebroventricular (icv) administration of (S)-3,5-DHPG at dosages of 0.01, 0.1, and 1.0 nmol influenced memory consolidation and retrieval. Under hypoxic conditions, the treatment was associated with anxiolytic activity and a modulation of stress responses related to oxygen deprivation [2].

Chemical Properties

Molecular Weight	183.16
Formula	C₈H₉NO₄
Cas No.	162870-29-3
Smiles	[C@H](C(O)=O)(N)C1=CC(O)=CC(O)=C1
Relative Density.	1.550 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (436.78 mM), Sonication is recommended.

H2O: 20 mg/mL (109.19 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.4597 mL	27.2985 mL	54.5971 mL	272.9854 mL
5 mM	1.0919 mL	5.4597 mL	10.9194 mL	54.5971 mL
10 mM	0.5460 mL	2.7299 mL	5.4597 mL	27.2985 mL
20 mM	0.2730 mL	1.3649 mL	2.7299 mL	13.6493 mL
50 mM	0.1092 mL	0.5460 mL	1.0919 mL	5.4597 mL
100 mM	0.0546 mL	0.2730 mL	0.5460 mL	2.7299 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc