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CV-6209

Name: CV-6209
Brand: TargetMol
SKU: T27102
Price: 129 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T27102Cas No. 100488-87-7

Alias CV6209, CV 6209

CV-6209 is a potent antagonist of the platelet-activating factor (PAF) receptor.

CV-6209

🥰Excellent

Catalog No. T27102Alias CV6209, CV 6209Cas No. 100488-87-7

CV-6209 is a potent antagonist of the platelet-activating factor (PAF) receptor.

Pack Size	Price	Availability
1 mg	$129	In Stock
5 mg	$569	In Stock
10 mg	$892	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:>99.99%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	CV-6209 is a potent antagonist of the platelet-activating factor (PAF) receptor.
In vitro	CV-6209 (0.2-2 μM; pretreatment for 30 min) inhibited PAF-induced degranulation of LAD2 and hLMC MC; CV-6209 (30 nM) inhibited the release of [3H]5-hydroxytryptamine from rabbit platelets stimulated by PAF [4].
In vivo	CV-6209 (i.v.) inhibited PAF (0.3 μg/kg; i.v.) induced hypotension in rats (ED50=0.009 mg/kg) but had no effect on arachidonic acid, histamine, bradykinin and isobarbital-induced hypotension [4]. CV-6209 (66 μg; i.v.) reduced asparaginase-induced hypersensitivity compared to untreated sensitized mice [5].
Synonyms	CV6209, CV 6209

Chemical Properties

Molecular Weight	642.31
Formula	C₃₄H₆₀ClN₃O₆
Cas No.	100488-87-7
Smiles	[Cl-].O=C(OCC(OC)COC(=O)N(C(=O)C)CC=1C=CC=C[N+]1CC)NCCCCCCCCCCCCCCCCCC
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (124.55 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5569 mL	7.7844 mL	15.5688 mL	77.8440 mL
5 mM	0.3114 mL	1.5569 mL	3.1138 mL	15.5688 mL
10 mM	0.1557 mL	0.7784 mL	1.5569 mL	7.7844 mL
20 mM	0.0778 mL	0.3892 mL	0.7784 mL	3.8922 mL
50 mM	0.0311 mL	0.1557 mL	0.3114 mL	1.5569 mL
100 mM	0.0156 mL	0.0778 mL	0.1557 mL	0.7784 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc