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Narsoplimab
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Catalog No. T76870Cas No. 2108782-45-0
Alias OMS 721
Narsoplimab (OMS 721) is a selective whole-human immunoglobulin gamma-4 (IgG4) monoclonal antibody and a mannan-binding lectin-associated serine protease-2 (MASP-2) inhibitor that binds MASP-2 to prevent lectin pathway activation and inhibit the agglutinin pathway. It is used to study diseases associated with hematopoietic stem cell transplantation in adults.
Narsoplimab
Narsoplimab
😃Good
Catalog No. T76870Alias OMS 721Cas No. 2108782-45-0
Narsoplimab (OMS 721) is a selective whole-human immunoglobulin gamma-4 (IgG4) monoclonal antibody and a mannan-binding lectin-associated serine protease-2 (MASP-2) inhibitor that binds MASP-2 to prevent lectin pathway activation and inhibit the agglutinin pathway. It is used to study diseases associated with hematopoietic stem cell transplantation in adults.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $263 | In Stock | In Stock | |
| 5 mg | $695 | In Stock | In Stock | |
| 10 mg | $1,070 | - | In Stock | |
| 25 mg | $1,590 | - | In Stock | |
| 50 mg | $2,150 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.56% (SEC-HPLC)
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| Description | Narsoplimab (OMS 721) is a selective whole-human immunoglobulin gamma-4 (IgG4) monoclonal antibody and a mannan-binding lectin-associated serine protease-2 (MASP-2) inhibitor that binds MASP-2 to prevent lectin pathway activation and inhibit the agglutinin pathway. It is used to study diseases associated with hematopoietic stem cell transplantation in adults. |
| In vitro | Narsoplimab (100 nM; 3 h; Vero E6 cells and Vero E6 cells with SARS-CoV-2) inhibits N protein-enhanced MASP-2 deposition[1]. |
| In vivo | Narsoplimab (10 mg/kg; i.v.; WT and Masp2-/- (KO) mice) reduced lymphocyte percentage (Lym%) and increased neutrophil percentage (Neu%)[1]. |
| Synonyms | OMS 721 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | MASP2 |
| Molecular Weight | 143.1 kDa |
| Cas No. | 2108782-45-0 |
| Color | Transparent |
| Appearance | Liquid |
| Isotype | Human IgG4SP lambda2 |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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