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GS87

Name: GS87
Brand: TargetMol
SKU: T8605
Price: 80 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8605Cas No. 919936-70-2

Alias 4-[5-[[(3-Phenyl-1,2,4-oxadiazol-5-yl)methyl]thio]-1,3,4-oxadiazol-2-yl]pyridine

GS87 is a highly specific inhibitor of GSK3 (glycogen synthase kinase 3) that induces extensive differentiation of AML cells.

GS87

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Purity: 98.86%

Catalog No. T8605Alias 4-[5-[[(3-Phenyl-1,2,4-oxadiazol-5-yl)methyl]thio]-1,3,4-oxadiazol-2-yl]pyridineCas No. 919936-70-2

GS87 is a highly specific inhibitor of GSK3 (glycogen synthase kinase 3) that induces extensive differentiation of AML cells.

Pack Size	Price	Availability
1 mg	$80	In Stock
5 mg	$178	In Stock
10 mg	$272	In Stock
25 mg	$448	In Stock
50 mg	$630	In Stock
100 mg	$852	In Stock
200 mg	$1,130	In Stock
1 mL x 10 mM (in DMSO)	$188	In Stock

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Purity:98.86%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	GS87 is a highly specific inhibitor of GSK3 (glycogen synthase kinase 3) that induces extensive differentiation of AML cells.
Targets&IC50	GSK-3β:521 nM, GSK-3α:415 nM
In vitro	GS87 potently inhibits growth of AML cells in mice with little effect on normal bone marrow cells. GS87 causes terminal differentiation of AML cells
Synonyms	4-[5-[[(3-Phenyl-1,2,4-oxadiazol-5-yl)methyl]thio]-1,3,4-oxadiazol-2-yl]pyridine

Chemical Properties

Molecular Weight	337.36
Formula	C₁₆H₁₁N₅O₂S
Cas No.	919936-70-2
Smiles	C(SC=1OC(=NN1)C=2C=CN=CC2)C3=NC(=NO3)C4=CC=CC=C4
Relative Density.	1.47±0.1 g/cm3 (20 °C, 760 mmHg)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (74.1 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9642 mL	14.8210 mL	29.6419 mL	148.2096 mL
5 mM	0.5928 mL	2.9642 mL	5.9284 mL	29.6419 mL
10 mM	0.2964 mL	1.4821 mL	2.9642 mL	14.8210 mL
20 mM	0.1482 mL	0.7410 mL	1.4821 mL	7.4105 mL
50 mM	0.0593 mL	0.2964 mL	0.5928 mL	2.9642 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc