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MEK Inhibitor II

🥰Excellent
Catalog No. T212593Cas No. 623163-52-0

MEK Inhibitor II (2-Chloro-3-(N-succinimidyl)-1,4-naphthoquinone) is a selective MEK1 inhibitor (IC50=0.38 μM) that inhibits tubulin polymerization in Trypanosoma cruzi (IC50=6 μM) and exhibits inhibitory activity against trypanosomes (IC50=2.77 μM).

MEK Inhibitor II

MEK Inhibitor II

🥰Excellent
Catalog No. T212593Cas No. 623163-52-0
MEK Inhibitor II (2-Chloro-3-(N-succinimidyl)-1,4-naphthoquinone) is a selective MEK1 inhibitor (IC50=0.38 μM) that inhibits tubulin polymerization in Trypanosoma cruzi (IC50=6 μM) and exhibits inhibitory activity against trypanosomes (IC50=2.77 μM).
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Product Introduction

Bioactivity
Description
MEK Inhibitor II (2-Chloro-3-(N-succinimidyl)-1,4-naphthoquinone) is a selective MEK1 inhibitor (IC50=0.38 μM) that inhibits tubulin polymerization in Trypanosoma cruzi (IC50=6 μM) and exhibits inhibitory activity against trypanosomes (IC50=2.77 μM).
Targets&IC50
Tubulin (T. cruzi):6 μM, T. cruzi:2.77 μM, MEK1:0.38 μM
Chemical Properties
Molecular Weight289.67
FormulaC14H8ClNO4
Cas No.623163-52-0
SmilesO=C1C(Cl)=C(C(=O)C=2C=CC=CC12)N3C(=O)CCC3=O
Relative Density.no data available
ColorGreen
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

MEKInhibitorII
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