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PROTACE3 Ligase Ligand-Linker Conjugates
E3 Ligase Ligand-Linker Conjugate consists of the ligand and linker from the E3 ubiquitin ligase, enabling the synthesis of PROTAC with target protein ligands. The E3 Ligase Ligand portion is often based on von Hippel-Lindau (VHL), MDM2, Cereblon (CRBN) , etc., while the linker portion commonly employs PEG chains, alkyl chains, or rigid aromatic rings. E3 Ligase Ligand-Linker Conjugate serves as a crucial tool for developing highly efficient and selective protein degradation agents.
TGN-020
Cited
TGN020
T510251987-99-6
TGN-020 is an inhibitor of Aquaporin 4 (AQP4, IC50: 3.1 μM), the most abundant water channel in the brain.
- $47
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QTY
CitedHaloPROTAC3
HaloPROTAC-3, HaloPROTAC 3, Halo PROTAC-3
T320431799506-07-2
HaloPROTAC3 (HaloPROTAC-3) is a conjugate of ligands for E3 and 16-atom-length linker and a degrader of HaloTag fusion proteins.
- $112
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QTY
Iberdomide Cited
CC-220
T77911323403-33-3
Iberdomide (CC-220) is a modulator of cereblon( IC50 value of 60 nM in a competitive TR-FRET assay).
- $39
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CitedThalidomide-NH-PEG1-NH2 hydrochloride
Pomalidomide-PEG1-C2-amine HCl, 4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
T94012154342-56-8
Thalidomide-NH-PEG1-NH2 hydrochloride (4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl) is a synthetic E3 ligase ligand-linker conjugate that incorporates the Thalidomide-based cereblon ligand and a linker[1].
- $40
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QTY
(S,R,S)-AHPC-Me
VHL ligand 2, E3 ligase Ligand 1A
T77521948273-02-6
(S,R,S)-AHPC-Me (E3 ligase Ligand 1A) (VHL ligand 2) is an (S,R,S)-AHPC-based VHL ligand used to recruit the von Hippel-Lindau (VHL) protein. It is utilized in the synthesis of ARV-771, a VHL E3 ligase-based BET PROTAC degrader that effectively degrades BET proteins in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM.
- $31
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QTY
(S,R,S)-AHPC-PEG4-N3
VHL Ligand-Linker Conjugates 5, VH032-PEG4-N3, E3 ligase Ligand-Linker Conjugates 4, (S,R,S)-AHPC-PEG4-Azide
T179211797406-81-5
(S,R,S)-AHPC-PEG4-N3 (VHL Ligand-Linker Conjugates 5) is a synthesized ligand-linker for E3 ligase-based systems, comprising the (S,R,S)-AHPC VHL ligand and a 4-unit PEG linker, commonly used in PROTAC technology.
- $30
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Thalidomide 4'-oxyacetamide-alkyl-C2-amine HCl
Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride
T398762341841-02-7
Thalidomide 4'-oxyacetamide-alkyl-C2-amine HCl is an E3 ligase ligand-linker conjugate containing the E3 ubiquitin ligase cereblon (CRBN) and linker for the synthesis of PROTAC.
- $30
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QTY
Pomalidomide-PEG6-NH2 hydrochloride
T398752341841-01-6
Pomalidomide-PEG6-NH2 hydrochloride is an E3 ligase ligand-linker coupler consisting of a PEG linker and the E3 ligase cereblon ligand, Pomalidomide, commonly used in the synthesis of PROTAC molecules.Pomalidomide is an anti angiogenic agent and immunomodulator.
- $68
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QTY
(S,R,S)-AHPC-PEG3-N3
VHL Ligand-Linker Conjugates 8, VH032-PEG3-N3, E3 ligase Ligand-Linker Conjugates 12
T179091797406-80-4
(S, R, S)-AHPC-PEG3-N3 (VHL Ligand-Linker Conjugates 8) is a synthesized E3 ligase ligand-linker conjugate. (S, R, S)-AHPC-PEG3-N3 incorporates the (S, R, S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology.
- $30
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Pomalidomide-PEG4-C2-NH2
E3 Ligase Ligand-Linker Conjugates 22, Cereblon Ligand-Linker Conjugates 8
T179162225940-52-1
Pomalidomide-PEG4-C2-NH2 (E3 Ligase Ligand-Linker Conjugates 22) is a synthesized E3 ligase ligand-linker conjugate incorporating the Pomalidomide-based cereblon ligand and 4-unit PEG linker.
- $30
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Pomalidomide-C4-OH
T40014
Pomalidomide-C4-OH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based CRBN ligand and linker used in PROTAC technology.
- $68
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(S,R,S)-AHPC-PEG4-NH2
VHL Ligand-Linker Conjugates 4, VH032-PEG4-NH2, E3 ligase Ligand-Linker Conjugates 7 Free Base
T15190L2010159-57-4
(S,R,S)-AHPC-PEG4-NH2 (VHL Ligand-Linker Conjugates 4) is a synthetic E3 ligase ligand-linker conjugate, consisting of a VHL ligand based on (S,R,S)-AHPC combined with a 4-unit PEG linker.
- $38
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Pomalidomide-C2-NH2 hydrochloride
T77612305369-00-8
Pomalidomide-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate incorporating the Pomalidomide-based cereblon ligand and a linker used in [PROTAC] technology.
- $49
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Thalidomide-PEG4-Propargyl
Thalidomide-O-PEG4-Propargyl
T93892098799-77-8
Thalidomide-PEG4-Propargyl (Thalidomide-O-PEG4-Propargyl) is a synthetic E3 ligase ligand-linker conjugate containing a Thalidomide-based cereblon ligand and a linker which can be used in PROTAC technology[1].
- $32
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Thalidomide 4'-ether-alkylC2-amine hydrochloride
halidomide-linker 6
T400302341840-99-9
Thalidomide 4'-ether-alkylC2-amine hydrochloride (halidomide-linker 6) is a synthesized E3 ligase ligand-linker conjugate.
- $30
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Pomalidomide 4'-PEG2-azide
T93872271036-45-2
Pomalidomide 4'-PEG2-azide is a synthetic E3 ligase ligand-linker conjugate, comprising a Pomalidomide-based cereblon ligand and a linker.
- $44
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Thalidomide-CH2CONH-C3-COOH
T40011
Thalidomide-CH2CONH-C3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based CRBN ligand and linker used in PROTAC technology.
- $68
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Thalidomide-CH2CONH-C2-COOH
T40012
Thalidomide-CH2CONH-C2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based CRBN ligand and linker used in PROTAC technology.
- $68
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Pomalidomide-CH2CONH-C2-COOH
T40006
Pomalidomide-CH2CONH-C2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based CRBN ligand and linker used in PROTAC technology.
- $68
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Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride
T188192376990-30-4
Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride, incorporating an E3 ligase ligand and a linker, can be used as an immunomodulator for the treatment of cancer.
- $42
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Pomalidomide-PEG4-C-COOH
E3 Ligase Ligand-Linker Conjugates 1, Cereblon Ligand -Linker Conjugates 1
T173252097938-44-6
Pomalidomide-PEG4-C-COOH (E3 Ligase Ligand-Linker Conjugates 1) is a synthesized E3 ligase ligand-linker conjugate that combines the Pomalidomide-based cereblon ligand and 4-unit PEG linker used in PROTAC technology.
- $30
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Pomalidomide-amino-PEG3-NH2 hydrochloride
T399532380273-75-4
Pomalidomide-amino-PEG3-NH2 hydrochloride is an E3 ligase ligand-linker conjugate containing a pomalidomide-based cereblon ligand and a linker, which can be used to synthesize PROTACs.
- $40
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GMB-475
T84882490599-18-1
GMB-475 is a BCR-ABL1 tyrosine kinase degrader based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. GMB-475 targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel Lindau (VHL).resulting in ubiquitination and subsequent degradation of th
- $45
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