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MN-64

Name: MN-64
Brand: TargetMol
SKU: T3168
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3168Cas No. 92831-11-3

Alias MN64

MN-64 is a tankyrases inhibitor, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition.

MN-64

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Purity: 99.93%

Catalog No. T3168Alias MN64Cas No. 92831-11-3

MN-64 is a tankyrases inhibitor, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$54	In Stock	In Stock
50 mg	$90	In Stock	In Stock
100 mg	$139	In Stock	In Stock
500 mg	$349	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.93%

Appearance:Solid

Color:White to Yellow

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COA HPLC HNMR

Product Introduction

MN-64 AI Summary

MN-64 exhibits a wide range of bioactivities, making it a versatile candidate in various biological and medical research applications. It shows potent inhibition of several enzymes within the PARP pathway, including ARTD1, ARTD2, TNKS1, and TNKS2, demonstrating high affinity with low IC50 values for these enzymes. Additionally, MN-64 inhibits the Tet-induced Flag-tagged mouse TRPM7 in HEK293 cells, significantly reducing channel-mediated cell death under Mg2+ conditions with an 80% inhibition rate. The compound also has notable antiviral properties, as it inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells at a 10 µM concentration with an inhibition rate of 20.62%, and shows SARS-CoV-2 3CL-Pro protease inhibition at 20 µM, with inhibition percentages of 7.17% to 13.86%. However, it displays inconsistent antiviral activity in VERO-6 cells, with inhibition ranging from -0.2% to -0.23% at 10 µM. Furthermore, MN-64 effectively inhibits human HDAC6 enzyme activity, with a significant percentage of inhibition in enzymatic assays and an IC50 value of 1497.0 nM for a custom peptide substrate. Lastly, it exhibits cytotoxicity against human HepG2 cells, with an IC50 value of 11100.0 nM, as measured by the CellTiter-Glo luminescent cell viability assay..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	MN-64 is a tankyrases inhibitor, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition.
Targets&IC50	ARTD1:19.1 μM, TNKS2:72 nM, ARTD2:39.4 μM, TNKS1:6 nM
Synonyms	MN64

Chemical Properties

Molecular Weight	264.32
Formula	C₁₈H₁₆O₂
Cas No.	92831-11-3
Smiles	CC(C)c1ccc(cc1)-c1cc(=O)c2ccccc2o1
Relative Density.	1.152 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 12 mg/mL (45.4 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.57 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7833 mL	18.9165 mL	37.8329 mL	189.1646 mL
5 mM	0.7567 mL	3.7833 mL	7.5666 mL	37.8329 mL
10 mM	0.3783 mL	1.8916 mL	3.7833 mL	18.9165 mL
20 mM	0.1892 mL	0.9458 mL	1.8916 mL	9.4582 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc