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Tarafenacin D-tartrate

Name: Tarafenacin D-tartrate
Brand: TargetMol
SKU: T16989
Price: 127 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16989Cas No. 1159101-48-0

Alias SVT-40776 D-tartrate

Tarafenacin D-tartrate (SVT-40776 D-tartrate) is a selective and potent muscarinic acetylcholine M3 receptor antagonist used in the study of overactive bladder and bronchial disorders.

Tarafenacin D-tartrate

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Purity: 99.86%

Catalog No. T16989Alias SVT-40776 D-tartrateCas No. 1159101-48-0

Tarafenacin D-tartrate (SVT-40776 D-tartrate) is a selective and potent muscarinic acetylcholine M3 receptor antagonist used in the study of overactive bladder and bronchial disorders.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$127	-	In Stock
5 mg	$217	5 days	5 days
25 mg	$690	6-8 weeks	6-8 weeks
50 mg	$897	6-8 weeks	6-8 weeks
100 mg	$1,520	6-8 weeks	6-8 weeks
1 mL x 10 mM (in DMSO)	$373	5 days	5 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.86%

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COA LCMS

Product Introduction

Bioactivity

Description	Tarafenacin D-tartrate (SVT-40776 D-tartrate) is a selective and potent muscarinic acetylcholine M3 receptor antagonist used in the study of overactive bladder and bronchial disorders.
In vitro	D-tartrate Tarafenacin was more selective for M(3) receptors than for M(2) receptors (Ki = 0.19 nmol.L(-1) for M(3) receptor affinity). Of the anticholinergic drugs tested, tarafenacin tartrate had the strongest inhibitory effect on carbachol-induced bladder contraction but did not affect atrial contraction over the same concentration range. Tarafenacin D-tartrate had the highest selectivity (199-fold) for urine and heart.The binding affinity of tarafenacin D-tartrate for the M5 mAChR (K(d) = 0.4 nM) was much higher than that of solifenacin (K(d) = 31 nM) for the same receptor.The binding affinity of tarafenacin D-tartrate for the M5 mAChR was much higher than that for solifenacin (K(d) = 31 nM). The calculated change in free energy of binding from solifenacin to tarafenacin tartrate (-2.3 ± 0.3 kcal/mol) agrees well with the experimentally derived change in free energy of binding (-2.58 kcal/mol), suggesting that our modeled structure of the M5 mAChR and its complex with the antagonist is reliable [1][2].
In vivo	Tarafenacin D-tartrate inhibited 25% of spontaneous bladder contractions at a very low dose (6.97 microg.kg(-1) i.v) in the guinea pig in vivo model, without affecting arterial blood pressure [1].
Synonyms	SVT-40776 D-tartrate

Chemical Properties

Molecular Weight	558.48
Formula	C₂₅H₂₆F₄N₂O₈
Cas No.	1159101-48-0
Smiles	O[C@@H]([C@H](O)C(O)=O)C(O)=O.Fc1cccc(c1)N(Cc1cc(F)c(F)c(F)c1)C(=O)O[C@H]1CN2CCC1CC2
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (143.25 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (5.91 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7906 mL	8.9529 mL	17.9057 mL	89.5287 mL
5 mM	0.3581 mL	1.7906 mL	3.5811 mL	17.9057 mL
10 mM	0.1791 mL	0.8953 mL	1.7906 mL	8.9529 mL
20 mM	0.0895 mL	0.4476 mL	0.8953 mL	4.4764 mL
50 mM	0.0358 mL	0.1791 mL	0.3581 mL	1.7906 mL
100 mM	0.0179 mL	0.0895 mL	0.1791 mL	0.8953 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc