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Lactic acid

Name: Lactic acid
Brand: TargetMol
SKU: TN6945
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN6945Cas No. 50-21-5

Alias 2-hydroxypropanoic acid

Lactic acid (2-hydroxypropanoic acid), a glycolysis end product, is a hydroxycarboxylic acid receptor 1 (HCAR1) activator (EC50=4.2-5 mM). Lactic acid can be used as a hemodynamic index in critically ill patients and has anti-tumor activity.

Lactic acid

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Catalog No. TN6945Alias 2-hydroxypropanoic acidCas No. 50-21-5

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$30	-	In Stock
100 mg	$40	In Stock	In Stock
500 mg	$64	In Stock	In Stock
1 g	$81	In Stock	In Stock
5 g	$129	-	In Stock
10 g	$169	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	Lactic acid (2-hydroxypropanoic acid), a glycolysis end product, is a hydroxycarboxylic acid receptor 1 (HCAR1) activator (EC50=4.2-5 mM). Lactic acid can be used as a hemodynamic index in critically ill patients and has anti-tumor activity.
Targets&IC50	GPR109B:1 mM (EC50), GPR81 (HCAR1):1 mM (EC50), GPR109A:1 mM (EC50)
In vitro	METHODS: : Effects on cell proliferation and migration of uveal melanoma after treatment with Lactic acid (20 mM) for 24 and 48 hours. RESULTS: Lactic acid led to a significant reduction in cell proliferation and migration. [1] Method: Uveal melanoma was treated with Lactic acid (20 mM) for 24 hours, and the protein expression level was detected by western blot. Result: Lactic acid promoted the increase in the protein expression levels of MCT1 and HCAR1. [1]
In vivo	METHODS: To detect the anti-tumor activity in vivo, Lactic acid (1.6 g/kg) was subcutaneously injected into Female C57BL/6 mice with MC38 colon cancer cells; pH 7.4 Once a day; From Day 8 to Day 30. RESULTS: Lactic acid demonstrated CD8+ T cell-dependent tumor growth inhibition in the MC38 colon cancer model. [2]
Synonyms	2-hydroxypropanoic acid

Chemical Properties

Molecular Weight	90.08
Formula	C₃H₆O₃
Cas No.	50-21-5
Smiles	CC(O)C(O)=O
Relative Density.	1.31g/cm3
Color	Transparent
Appearance	Liquid

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (999.11 mM), Sonication is recommended.

H2O: 100 mg/mL (1110.12 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 5 mg/mL (55.51 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	11.1012 mL	55.5062 mL	111.0124 mL	555.0622 mL
5 mM	2.2202 mL	11.1012 mL	22.2025 mL	111.0124 mL
10 mM	1.1101 mL	5.5506 mL	11.1012 mL	55.5062 mL
20 mM	0.5551 mL	2.7753 mL	5.5506 mL	27.7531 mL
50 mM	0.2220 mL	1.1101 mL	2.2202 mL	11.1012 mL
100 mM	0.1110 mL	0.5551 mL	1.1101 mL	5.5506 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc