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Anti-Phospho-BRCA1 (Ser1457) Polyclonal Antibody (Synonyms: p-BRCA1 (Ser1457), p-BRCA1 (S1457), BRCA1 (p-Ser14...)
Catalog No. TMAC-00467 Copy Product Info
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Anti-Phospho-BRCA1 (Ser1457) Polyclonal Antibody is a Rabbit antibody targeting Phospho-BRCA1 (Ser1457). Anti-Phospho-BRCA1 (Ser1457) Polyclonal Antibody can be used in WB.
Anti-Phospho-BRCA1 (Ser1457) Polyclonal Antibody
Copy Product Info🥰Excellent
Catalog No. TMAC-00467
Synonyms p-BRCA1 (Ser1457), p-BRCA1 (S1457), BRCA1 (p-Ser1457), BRCA1 (p-S1457)
Anti-Phospho-BRCA1 (Ser1457) Polyclonal Antibody is a Rabbit antibody targeting Phospho-BRCA1 (Ser1457). Anti-Phospho-BRCA1 (Ser1457) Polyclonal Antibody can be used in WB.
Anti-Phospho-BRCA1
(Ser1457) Polyclonal Antibody
(Ser1457) Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $218 | 7-10 days | 7-10 days | |
| 100 μL | $317 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Related Conjugates and Formulations
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| Description | Anti-Phospho-BRCA1 (Ser1457) Polyclonal Antibody is a Rabbit antibody targeting Phospho-BRCA1 (Ser1457). Anti-Phospho-BRCA1 (Ser1457) Polyclonal Antibody can be used in WB. |
| Synonyms | p-BRCA1 (Ser1457), p-BRCA1 (S1457), BRCA1 (p-Ser1457), BRCA1 (p-S1457) |
| Ig Type | IgG |
| Reactivity | Human |
| Verified Activity | 1. Western blot analysis of extracts from 293 cells (Lane 2), using BRCA1 (Phospho-Ser1457) Antibody TMAC-00467. The lane on the left is treated with antigen-specific peptide.  |
| Application | |
| Recommended Dose | WB: 1:500-1000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Construction | Polyclonal Antibody |
| Purification | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Appearance | Liquid |
| Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation |
| Conjucates | Unconjugated |
| Others Formats | Phospho |
| Immunogen | Peptide sequence around phosphorylation site of Serine 1457 (L-T-S(p)-Q-K) derived from Human BRCA1 |
| Antigen Species | human |
| Uniprot ID |
| Molecular Weight | Actual: 220 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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