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YYA-021

Name: YYA-021
Brand: TargetMol
SKU: T6256
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T6256Cas No. 144217-65-2

Alias YYA 021

YYA-021 inhibits HIV entry, with high anti-HIV activity and low cytotoxicity.

YYA-021

🥰Excellent

Purity: 99.87%

Catalog No. T6256Alias YYA 021Cas No. 144217-65-2

YYA-021 inhibits HIV entry, with high anti-HIV activity and low cytotoxicity.

Pack Size	Price	Availability
10 mg	$30	In Stock
25 mg	$65	In Stock
50 mg	$90	In Stock
100 mg	$117	In Stock
200 mg	$173	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Batch Information

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Purity:99.87%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	YYA-021 inhibits HIV entry, with high anti-HIV activity and low cytotoxicity.
Targets&IC50	HIV:8.4 μM
In vitro	YYA-021 enhances the neutralization sensitivity of simian-human immunodeficiency virus (SHIV) carrying the envelope from the clade B clinical human immunodeficiency virus type 1 (HIV-1) isolate MNA. [1]
In vivo	In rats and rhesus macaques, YYA-021 (i.v.) shows moderate half-lives, wide tissue distribution and relatively high distribution volumes. [2]
Synonyms	YYA 021

Chemical Properties

Molecular Weight	317.43
Formula	C₁₈H₂₇N₃O₂
Cas No.	144217-65-2
Smiles	Cc1ccc(NC(=O)C(=O)NC2CC(C)(C)NC(C)(C)C2)cc1
Relative Density.	1.11 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 11 mg/mL (34.65 mM), Sonication is recommended.

H2O: < 0.1 mg/mL (insoluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1503 mL	15.7515 mL	31.5030 mL	157.5150 mL
5 mM	0.6301 mL	3.1503 mL	6.3006 mL	31.5030 mL
10 mM	0.3150 mL	1.5752 mL	3.1503 mL	15.7515 mL
20 mM	0.1575 mL	0.7876 mL	1.5752 mL	7.8758 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc