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Ibandronic acid

Name: Ibandronic acid
Brand: TargetMol
SKU: T1599
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1599Cas No. 114084-78-5

Alias Bonviva, Boniva, Bondronat

Ibandronic acid (Bonviva) is a third-generation amino-bisphosphonate with anti-resorptive and anti-hypercalcemic activities.

Ibandronic acid

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🥰Excellent

Catalog No. T1599Alias Bonviva, Boniva, BondronatCas No. 114084-78-5

Ibandronic acid (Bonviva) is a third-generation amino-bisphosphonate with anti-resorptive and anti-hypercalcemic activities.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$30	In Stock	In Stock
25 mg	$35	In Stock	In Stock
50 mg	$40	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Ibandronic acid AI Summary

Ibandronic acid exhibits diverse bioactivities and has shown significant potency in various assays. It demonstrates in vitro growth inhibition of Trypanosoma brucei rhodesiense bloodstream forms with an IC50 value of 960.0 nM and a predicted pIC50 value close to this. The compound also effectively inhibits the human recombinant farnesyl pyrophosphate synthase (FPPSase) and geranylgeranyl diphosphate synthase (GGPPSase) with IC50 values of 20.0 nM and approximately 79432.82 nM, respectively. Additionally, it reduces hypercalcemia in TPTX rats at an ED50 of 0.0011 mg/kg and exhibits bone resorption inhibition activity in rats at a minimum effective dose of 0.0001 mg/kg. In the context of immunomodulation, Ibandronic acid inhibits TNF-alpha release in gamma-delta T cells with IC50 values ranging around 31,000 nM and activates these cells at an EC50 concentration of 1000.0 nM. It also inhibits osteoclast formation in RAW264.7 cells, diminishing their count under specified conditions. Despite its broad spectrum of actions, the compound shows no significant antibacterial activity against Escherichia coli W3110. However, it inhibits the growth of Toxoplasma gondii in human foreskin fibroblast monolayer cells with an IC50 of 54920.0 nM and shows selectivity towards the parasite with a LD50 of 10.4 μM for KB cells. Pharmacokinetically, Ibandronic acid exhibits a fraction unbound of 0.15 in humans, a volume of distribution at steady state of 0.55 L/kg, and a clearance of 1.8 mL/min/kg, with a half-life of 14.0 hours following intravenous administration. While studies indicate moderate liver toxicity with elevated liver enzyme levels, there is no significant evidence of severe hepatic side effects or liver disease. Moreover, it inhibits HDAC6 enzyme activity and human ACMSD, reducing Quinolinic acid levels substantially. Overall, Ibandronic acid interacts with a wide variety of receptors, functioning as both an agonist and antagonist, suggesting extensive pharmacological potential in targeting multiple biological processes and therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Ibandronic acid (Bonviva) is a third-generation amino-bisphosphonate with anti-resorptive and anti-hypercalcemic activities.
Synonyms	Bonviva, Boniva, Bondronat

Chemical Properties

Molecular Weight	319.23
Formula	C₉H₂₃NO₇P₂
Cas No.	114084-78-5
Smiles	CCCCCN(C)CCC(O)(P(O)(O)=O)P(O)(O)=O
Relative Density.	1.449 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 50 mg/mL (156.63 mM), Sonication is recommended.

DMSO: Slightly soluble

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	3.1325 mL	15.6627 mL	31.3254 mL	156.6269 mL
5 mM	0.6265 mL	3.1325 mL	6.2651 mL	31.3254 mL
10 mM	0.3133 mL	1.5663 mL	3.1325 mL	15.6627 mL
20 mM	0.1566 mL	0.7831 mL	1.5663 mL	7.8313 mL
50 mM	0.0627 mL	0.3133 mL	0.6265 mL	3.1325 mL
100 mM	0.0313 mL	0.1566 mL	0.3133 mL	1.5663 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc