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ACHP
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Catalog No. T22021Cas No. 406208-42-2
Alias IKK-2 Inhibitor VIII
ACHP (IKK-2 Inhibitor VIII) is a novel selective and potent IKK inhibitor with inhibitory effects on IKK-α and IKK-β. ACHP has anti-HIV-1 activity and inhibits HIV-1 long terminal repeat (LTR)-driven gene expression through inhibition of NF-κB activation, inhibits TNF-α-induced NF-κB (p65) recruitment to the HIV-1 LTR, and inhibits TNF-α-induced NF-κB (p65) recruitment to the HIV-1 LTR. ACHKP has anti-HIV-1 activity and inhibits TNF-α-induced recruitment of NF-κB (p65) to the HIV-1 LTR.
ACHP
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Purity: 98.77%
Catalog No. T22021Alias IKK-2 Inhibitor VIIICas No. 406208-42-2
ACHP (IKK-2 Inhibitor VIII) is a novel selective and potent IKK inhibitor with inhibitory effects on IKK-α and IKK-β. ACHP has anti-HIV-1 activity and inhibits HIV-1 long terminal repeat (LTR)-driven gene expression through inhibition of NF-κB activation, inhibits TNF-α-induced NF-κB (p65) recruitment to the HIV-1 LTR, and inhibits TNF-α-induced NF-κB (p65) recruitment to the HIV-1 LTR. ACHKP has anti-HIV-1 activity and inhibits TNF-α-induced recruitment of NF-κB (p65) to the HIV-1 LTR.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $48 | In Stock | In Stock | |
| 5 mg | $108 | In Stock | In Stock | |
| 10 mg | $162 | In Stock | In Stock | |
| 25 mg | $268 | In Stock | In Stock | |
| 50 mg | $392 | In Stock | In Stock | |
| 100 mg | $668 | - | In Stock | |
| 200 mg | $1,090 | - | In Stock | |
| 500 mg | $2,180 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.77%
Appearance:Solid
Color:Yellow
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Product Introduction
ACHP AI Summary
ACHP exhibits significant bioactivities, including potent inhibitory effects on inflammatory pathways and cytokine production. It inhibits I-kappa-B-kinase beta (IKK beta) with an IC50 of 8.5 nM and demonstrates specific inhibitory effects on TNF-alpha-induced RANTES and VCAM-1 production, NF-KB transactivation, as well as IL-1beta, IL-6, and TNFalpha production in human PBMC cells. Additionally, it inhibits LPS-induced proliferation in mouse B-cells. The compound shows some solubility at 120.0 ug.mL-1, oral bioavailability in rats at 16%, and moderate clearance in rat at 5.5 mL.min-1.kg-1, but low oral bioavailability in mice at 0.00000623%. In assays, ACHP demonstrated complete (100%) inhibition of human IKKbeta activity at 10 uM concentration. Moreover, it exhibits antiviral activity by inhibiting SARS-CoV-2 3CL-Pro protease with 13.44% inhibition at 20 µM concentration and reduces SARS-CoV-2-induced cytotoxicity in VERO-6 cells by 0.85% after 48 hours at 10 µM with 0.01 MOI virus exposure..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | ACHP (IKK-2 Inhibitor VIII) is a novel selective and potent IKK inhibitor with inhibitory effects on IKK-α and IKK-β. ACHP has anti-HIV-1 activity and inhibits HIV-1 long terminal repeat (LTR)-driven gene expression through inhibition of NF-κB activation, inhibits TNF-α-induced NF-κB (p65) recruitment to the HIV-1 LTR, and inhibits TNF-α-induced NF-κB (p65) recruitment to the HIV-1 LTR. ACHKP has anti-HIV-1 activity and inhibits TNF-α-induced recruitment of NF-κB (p65) to the HIV-1 LTR. |
| Targets&IC50 | IKKβ:8.5 nM, IKKα:250 nM |
| Synonyms | IKK-2 Inhibitor VIII |
| Molecular Weight | 364.44 |
| Formula | C21H24N4O2 |
| Cas No. | 406208-42-2 |
| Smiles | N#CC1=C(N=C(C=C1C2CCNCC2)C=3C(O)=CC=CC3OCC4CC4)N |
| Relative Density. | no data available |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 5 mg/mL (13.72 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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