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Ezutromid

Name: Ezutromid
Brand: TargetMol
SKU: T3424
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3424Cas No. 945531-77-1

Alias VOX-C1100, SMT C1100, BMN 195

Ezutromid (BMN 195) is a translation modulator of Small utrophin (EC50: 0.4 uM). Ezutromid is an orally bioavailable small molecule that transcriptionally upregulates the utrophin gene, increasing both utrophin mRNA and protein. Through this action, Ezutromid increases muscle function in dystrophin-deficient MDX mice, a mouse model of muscular dystrophy.

Ezutromid

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Purity: 99.76%

Catalog No. T3424Alias VOX-C1100, SMT C1100, BMN 195Cas No. 945531-77-1

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$48	In Stock	In Stock
10 mg	$77	In Stock	In Stock
25 mg	$158	In Stock	In Stock
50 mg	$253	In Stock	In Stock
100 mg	$407	In Stock	In Stock
200 mg	$566	-	In Stock
1 mL x 10 mM (in DMSO)	$53	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.76%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Ezutromid AI Summary

Ezutromid activates the UTRN promoter leading to upregulation of utrophin production in mouse H2K cells, with an EC50 of 910.0 nM. At 10 µM, it activates the UTRN promoter to 143.0% after 72 hours. In CD1 mice, a 50 mg/kg intraperitoneal dose results in a Cmax of 4404.27 nM, Tmax of 0.25 hours, and an AUC of 420000.0 ng.hr.mL-1. It has a half-life of 1.358 hours in mouse liver microsomes and 1.75 hours in human liver microsomes. The compound demonstrates high aqueous solubility (3000.0 nM) and significant plasma protein binding in both mouse and human plasma. Additionally, Ezutromid exhibits modulation of human utrophinA expression in mouse cells with an EC50 of 187.0 nM and induces CYP2B and CYP1A1/2 enzymes, increasing PROD and EROD activity in minipigs. It also shows inhibition of CYP1A2 in human liver microsomes and has a potential role in modulating AhR pathways due to its binding affinity with a Kd of 50.0 nM. The compound demonstrates intrinsic clearance and microsomal stability in liver microsomes and hepatocytes of both mouse and human cells, indicating good stability and clearance characteristics across species. In a DMD disease mouse model myoblasts, it upregulates utrophin mRNA by 1.7-fold at 3 µM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Ezutromid (BMN 195) is a translation modulator of Small utrophin (EC50: 0.4 uM). Ezutromid is an orally bioavailable small molecule that transcriptionally upregulates the utrophin gene, increasing both utrophin mRNA and protein. Through this action, Ezutromid increases muscle function in dystrophin-deficient MDX mice, a mouse model of muscular dystrophy.
Targets&IC50	Small utrophin:0.4 μM
Synonyms	VOX-C1100, SMT C1100, BMN 195

Chemical Properties

Molecular Weight	337.39
Formula	C₁₉H₁₅NO₃S
Cas No.	945531-77-1
Smiles	S(CC)(=O)(=O)C=1C=C2N=C(OC2=CC1)C3=CC4=C(C=C3)C=CC=C4
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 12 mg/mL (35.57 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9639 mL	14.8196 mL	29.6393 mL	148.1964 mL
5 mM	0.5928 mL	2.9639 mL	5.9279 mL	29.6393 mL
10 mM	0.2964 mL	1.4820 mL	2.9639 mL	14.8196 mL
20 mM	0.1482 mL	0.7410 mL	1.4820 mL	7.4098 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc