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Gliquidone

Name: Gliquidone
Brand: TargetMol
SKU: T0371
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0371Cas No. 33342-05-1

Alias Glurenorm, AR-DF 26

Gliquidone (AR-DF 26) is a potent, second-generation sulfonylurea with antihyperglycemic activity, exhibiting greater binding affinity to SUR1 and increased potency compared to first-generation compounds. Additionally, this agent exerts peroxisome proliferator-activated receptor (PPAR) gamma agonistic activity.

Gliquidone

🥰Excellent

Purity: 99.93%

Catalog No. T0371Alias Glurenorm, AR-DF 26Cas No. 33342-05-1

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$35	In Stock	In Stock
50 mg	$47	In Stock	In Stock
100 mg	$57	In Stock	In Stock
500 mg	$138	-	In Stock
1 g	$197	-	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.93%

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COA

Product Introduction

Bioactivity

Description	Gliquidone (AR-DF 26) is a potent, second-generation sulfonylurea with antihyperglycemic activity, exhibiting greater binding affinity to SUR1 and increased potency compared to first-generation compounds. Additionally, this agent exerts peroxisome proliferator-activated receptor (PPAR) gamma agonistic activity.
Targets&IC50	K+ channel:27.2 nM
In vitro	Intraventricular administration of 0.06–16 μg Gliquidone to each mouse counteracts the antinociceptive effects of tramadol, morphine, and methadone. A dose of 6 μg Gliquidone intraventricularly administered to each mouse inhibits the antinociceptive responses induced by subcutaneous injections of 0.125 mg/kg clonidine and 0.30 mg/kg chlorthalidone; however, a 3 μg dose is ineffective. In male Swiss albino mice, intraventricular injections of 0.1–1.0 μg Gliquidone dose-dependently suppress the antinociceptive effects of amitriptyline and chlorphenamine. In diabetic rats, a 10 mg/kg dose of Gliquidone significantly reduces blood pressure, diminishes non-enzymatic glycation, lowers total protein levels in the lens, and notably increases glutathione levels in the lens.
Synonyms	Glurenorm, AR-DF 26

Chemical Properties

Molecular Weight	527.63
Formula	C₂₇H₃₃N₃O₆S
Cas No.	33342-05-1
Smiles	CC1(C)C=2C(C(=O)N(CCC3=CC=C(S(NC(NC4CCCCC4)=O)(=O)=O)C=C3)C1=O)=CC(OC)=CC2
Relative Density.	1.34 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 97 mg/mL (183.84 mM), Sonication is recommended.

Ethanol: 6 mg/mL (11.37 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (6.25 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8953 mL	9.4763 mL	18.9527 mL	94.7634 mL
5 mM	0.3791 mL	1.8953 mL	3.7905 mL	18.9527 mL
10 mM	0.1895 mL	0.9476 mL	1.8953 mL	9.4763 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.0948 mL	0.4738 mL	0.9476 mL	4.7382 mL
50 mM	0.0379 mL	0.1895 mL	0.3791 mL	1.8953 mL
100 mM	0.0190 mL	0.0948 mL	0.1895 mL	0.9476 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc