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JH-X-119-01 hydrochloride

Catalog No. T40225 CAS 2591344-30-6

JH-X-119-01 hydrochloride is a potent and selective inhibitor of interleukin-1 receptor-associated kinases 1 (IRAK1). It effectively alleviates lipopolysaccharide (LPS)-induced sepsis in mice.

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JH-X-119-01 hydrochloride Chemical Structure

JH-X-119-01 hydrochloride, CAS 2591344-30-6

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Description	JH-X-119-01 hydrochloride is a potent and selective inhibitor of interleukin-1 receptor-associated kinases 1 (IRAK1). It effectively alleviates lipopolysaccharide (LPS)-induced sepsis in mice.
In vitro	Jh-X-119-01 at a concentration of 10 μM effectively reduces NF-κB phosphorylation and decreases the mRNA expression levels of IL-6 and TNFα in LPS-stimulated macrophages in vitro, demonstrating its anti-inflammatory properties. This compound also specifically targets and inhibits IRAK1 phosphorylation. Employing Western Blot analysis in both RAW 264.7 and THP-1 cell lines, it was observed that a 15-minute incubation with Jh-X-119-01 significantly diminished LPS (100 ng/mL)-induced phosphorylation of IκBα and NF-κB-P65, further confirming its mechanism of action.
In vivo	Jh-X-119-01 enhances survival rates and reduces immunological pathologies in LPS-challenged mice, with efficacy depending on dosage. Administered intraperitoneally to C57BL/6 male mice weighing 20-22 grams, a 5 mg/kg dose significantly increases survival, with further improvements seen at 10 mg/kg. This compound provides protection against LPS-induced sepsis; control mice treated with vehicle experienced a survival rate of 13.3% after 5 days, whereas survival rates for mice treated with 5 mg/kg and 10 mg/kg of Jh-X-119-01 were 37.5% and 56.3%, respectively.

Molecular Weight	488.93
Formula	C25H21ClN6O3
CAS No.	2591344-30-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Bin Pan, et al. Selective inhibition of interleukin-1 receptor-associated kinase 1 ameliorates lipopolysaccharide-induced sepsis in mice. Int Immunopharmacol. 2020 Aug;85:106597.

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Keywords

JH-X-119-01 hydrochloride 2591344-30-6 JH-X-119-01 Hydrochloride JHX11901 hydrochloride JH X 119 01 hydrochloride inhibitor inhibit

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