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Lupartumab Amadotin
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Catalog No. T9901A-1023Cas No. 1640972-00-4
Alias BAY 1129980, Anti-C4.4a antibody-drug conjugates
Lupartumab Amadotin (BAY 1129980) is an antibody-drug conjugate (ADC) composed of a fully human C4.4A (LYPD3) targeting monoclonal antibody (BAY 1135626) linked through a non-cleavable alkyl hydrazide linker to a novel, highly potent microtubule-disrupting cytotoxic auristatin derivative. Lupartumab Amadotin is utilized in research on non-small cell lung cancer.
Lupartumab Amadotin
Lupartumab Amadotin
😃Good
Catalog No. T9901A-1023Alias BAY 1129980, Anti-C4.4a antibody-drug conjugatesCas No. 1640972-00-4
Lupartumab Amadotin (BAY 1129980) is an antibody-drug conjugate (ADC) composed of a fully human C4.4A (LYPD3) targeting monoclonal antibody (BAY 1135626) linked through a non-cleavable alkyl hydrazide linker to a novel, highly potent microtubule-disrupting cytotoxic auristatin derivative. Lupartumab Amadotin is utilized in research on non-small cell lung cancer.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | Inquiry | Inquiry | Inquiry | |
| 5 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Lupartumab Amadotin (BAY 1129980) is an antibody-drug conjugate (ADC) composed of a fully human C4.4A (LYPD3) targeting monoclonal antibody (BAY 1135626) linked through a non-cleavable alkyl hydrazide linker to a novel, highly potent microtubule-disrupting cytotoxic auristatin derivative. Lupartumab Amadotin is utilized in research on non-small cell lung cancer. |
| In vitro | Lupartumab Amadotin (BAY 1129980; 0-2 nM; 72 h) exhibits significant antiproliferative activity in cell lines with endogenous C4.4A expression. It also inhibits the proliferation of C4.4A-transfected A549 lung cancer cells, showing selectivity when compared to a non-targeting control ADC. |
| In vivo | Lupartumab Amadotin (BAY 1129980; 1.9-15 mg/kg; i.v.; Q4D×3) demonstrates antitumor activity in C4.4A-positive NCI-H292 and NCI-H322 NSCLC xenograft models. Additionally, Lupartumab Amadotin (BAY 1129980; 7.5 and 15 mg/kg; i.v.; Q4D×3) exhibits target-dependent antitumor efficacy in NSCLC patient-derived xenograft (PDX) models focusing on the C4.4A target. |
| Synonyms | BAY 1129980, Anti-C4.4a antibody-drug conjugates |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | ＜ 1.0 EU/mg |
| Target | C4.4A (LYPD3) |
| Cas No. | 1640972-00-4 |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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