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Lupartumab Amadotin
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Catalog No. T9901A-1023Cas No. 1640972-00-4
Alias BAY 1129980, Anti-C4.4a antibody-drug conjugates
Lupartumab Amadotin (BAY 1129980) is an antibody-drug conjugate (ADC) composed of a fully human C4.4A (LYPD3) targeting monoclonal antibody (BAY 1135626) linked through a non-cleavable alkyl hydrazide linker to a novel, highly potent microtubule-disrupting cytotoxic auristatin derivative. Lupartumab Amadotin is utilized in research on non-small cell lung cancer.
Lupartumab Amadotin
Lupartumab Amadotin
😃Good
Catalog No. T9901A-1023Alias BAY 1129980, Anti-C4.4a antibody-drug conjugatesCas No. 1640972-00-4
Lupartumab Amadotin (BAY 1129980) is an antibody-drug conjugate (ADC) composed of a fully human C4.4A (LYPD3) targeting monoclonal antibody (BAY 1135626) linked through a non-cleavable alkyl hydrazide linker to a novel, highly potent microtubule-disrupting cytotoxic auristatin derivative. Lupartumab Amadotin is utilized in research on non-small cell lung cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | Inquiry | Backorder | |
| 5 mg | Inquiry | Backorder |
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Chemical Properties
| Description | Lupartumab Amadotin (BAY 1129980) is an antibody-drug conjugate (ADC) composed of a fully human C4.4A (LYPD3) targeting monoclonal antibody (BAY 1135626) linked through a non-cleavable alkyl hydrazide linker to a novel, highly potent microtubule-disrupting cytotoxic auristatin derivative. Lupartumab Amadotin is utilized in research on non-small cell lung cancer. |
| In vitro | Lupartumab Amadotin (BAY 1129980; 0-2 nM; 72 h) exhibits significant antiproliferative activity in cell lines with endogenous C4.4A expression. It also inhibits the proliferation of C4.4A-transfected A549 lung cancer cells, showing selectivity when compared to a non-targeting control ADC. |
| In vivo | Lupartumab Amadotin (BAY 1129980; 1.9-15 mg/kg; i.v.; Q4D×3) demonstrates antitumor activity in C4.4A-positive NCI-H292 and NCI-H322 NSCLC xenograft models. Additionally, Lupartumab Amadotin (BAY 1129980; 7.5 and 15 mg/kg; i.v.; Q4D×3) exhibits target-dependent antitumor efficacy in NSCLC patient-derived xenograft (PDX) models focusing on the C4.4A target. |
| Synonyms | BAY 1129980, Anti-C4.4a antibody-drug conjugates |
| Cas No. | 1640972-00-4 |
Storage & Solubility Information
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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