**MICA*018 Protein, Human, Recombinant (His)**

Name: MICA*018 Protein, Human, Recombinant (His)
Brand: TargetMol
SKU: TMPY-02053U
Rating: 4.5 (1 reviews)

(Synonyms: PERB11.1, MIC-A, MHC class I polypeptide-related sequence A, MGC21250, MGC111087, FLJ60820, FLJ36918, DAMA-345G11.2) Copy Product Info

Synonyms: PERB11.1, MIC-A, MHC class I polypeptide-related sequence A, MGC21250, MGC111087, FLJ60820, FLJ36918, DAMA-345G11.2

Catalog No. TMPY-02053U Copy Product Info

MICA*018 Protein, Human, Recombinant (His) is expressed in HEK293 Cells. The accession number is AAH16929.1.

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Pack Size	Price	USA Stock	Global Stock
5 µg	$37	7-10 days	7-10 days
10 µg	$56	7-10 days	7-10 days
20 µg	$88	7-10 days	7-10 days
50 µg	$168	7-10 days	7-10 days
100 µg	$278	7-10 days	7-10 days
200 µg	$519	7-10 days	7-10 days
500 µg	$1,180	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Loaded Human NKG2D-Fc on Protein A Biosensor, can bind Human MICA-His with an affinity constant of 24.6 nM as determined in BLI assay. (Regularly tested)
Description	MICA*018 Protein, Human, Recombinant (His) is expressed in HEK293 Cells. The accession number is AAH16929.1.
Species	Human
Expression System	HEK293 Cells
Tag	C-6xHis
Accession Number	AAH16929.1
Construction	Glu24-Gln308
Protein Purity	> 95% as determined by SDS-PAGE
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution	Reconstitute the lyophilized protein in sterile deionized water. The product concentration should not be less than 100 μg/mL. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	PERB11.1, MIC-A, MHC class I polypeptide-related sequence A, MGC21250, MGC111087, FLJ60820, FLJ36918, DAMA-345G11.2
Research Background	MHC Class I Polypeptide-Related Sequence A (MICA) is a transmembrane glycoprotein that functions as a ligand for human NKG2D. Unlike classical MHC class I molecules, MICA does not form a heterodimer with beta-2-microglobulin. MICA shares 85% amino acid identity with a closely related protein, MICB. MICA acts as a stress-induced self-antigen that is recognized by NK cells, NKT cells, and most of the subtypes of T cells. As a Ligand for the KLRK1/NKG2D receptor, MICA binds to KLRK1 leads to cell lysis. MICA functions as an antigen for gamma delta T cells and is frequently expressed in epithelial tumors. MICA antigens are able to elicit the synthesis of alloantibodies in transplant recipients. Studies have shown that anti-MICA antibodies are associated with acute renal allograft rejection and failure. MICA recognition is involved in tumor surveillance, viral infections, and autoimmune diseases.

Chemical Properties

Molecular Weight

33.87 kDa (Predicted); 60 kDa (Reducing conditions)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.