Loaded Human NKG2D-Fc on Protein A Biosensor, can bind Human MICA-His with an affinity constant of 24.6 nM as determined in BLI assay. (Regularly tested)

MICA*018 Protein, Human, Recombinant (His) is expressed in HEK293 Cells. The accession number is AAH16929.1.

Human

HEK293 Cells

PERB11.1,MIC-A,MHC class I polypeptide-related sequence A,MGC21250,MGC111087,FLJ60820,FLJ36918,DAMA-345G11.2

Glu24-Gln308

> 95% as determined by SDS-PAGE

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

MHC Class I Polypeptide-Related Sequence A (MICA) is a transmembrane glycoprotein that functions as a ligand for human NKG2D. Unlike classical MHC class I molecules, MICA does not form a heterodimer with beta-2-microglobulin. MICA shares 85% amino acid identity with a closely related protein, MICB. MICA acts as a stress-induced self-antigen that is recognized by NK cells, NKT cells, and most of the subtypes of T cells. As a Ligand for the KLRK1/NKG2D receptor, MICA binds to KLRK1 leads to cell lysis. MICA functions as an antigen for gamma delta T cells and is frequently expressed in epithelial tumors. MICA antigens are able to elicit the synthesis of alloantibodies in transplant recipients. Studies have shown that anti-MICA antibodies are associated with acute renal allograft rejection and failure. MICA recognition is involved in tumor surveillance, viral infections, and autoimmune diseases.