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Anti-JAM-A Antibody-APC (5E755) is a APC-conjugated Mouse antibody targeting JAM-A. Anti-JAM-A Antibody-APC (5E755) can be used in FCM.
Description | Anti-JAM-A Antibody-APC (5E755) is a APC-conjugated Mouse antibody targeting JAM-A. Anti-JAM-A Antibody-APC (5E755) can be used in FCM. |
Ig Type | Monoclonal Mouse IgG1 |
Clone | 5E755 |
Reactivity | Human |
Verified Activity | Profile of anti-JAM-A (CD321) reactivity on SKBR3 cells analyzed by flow cytometry. |
Application | FCM |
Recommended Dose | 2 μl/Test, 0.1 mg/ml |
Antibody Type | Monoclonal |
Host Species | Mouse |
Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human JAM-A / F11R / CD321 (rh JAM-A / F11R / CD321; TMPY-01035; NP_058642.1; Met 1-Ala 242) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
Purification | Protein A |
Appearance | Liquid |
Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
Research Background | Junctional adhesion molecule-A (JAM-A), also known as F11 receptor (F11R) or Cluster of Differentiation 321 (CD321), is a transmembrane protein expressed at tight junctions of epithelial and endothelial cells, as well as on circulating leukocytes. JAM-A protein serves as a serotype-independent receptor for mammalian orthoreoviruses (reoviruses). It is also a ligand for the integrin LFA1, involves in leukocyte transmigration. As a cell adhesion molecule of the immunoglobulin superfamily, JAM-A protein involves in platelet adhesion, secretion and aggregation, and plays a crucial role in inflammatory thrombosis and atherosclerosis. In addition, it may be a potential therapeutic target for breast cancer. |
Conjucates | APC |
Others Formats | Unconjugated/FITC/PE |
Antibody Types Available | 4 |
Immunogen | Recombinant Human JAM-A / F11R / CD321 protein (TMPY-01035) |
Antigen Species | Human |
Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
Transport | Shipping with blue ice. |
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