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Imipramine hydrochloride

Name: Imipramine hydrochloride
Brand: TargetMol
SKU: T7941
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7941Cas No. 113-52-0

Alias Tofranil, Melipramine, Imipramine HCl, Imipramine (hydrochloride), G 22355

Imipramine hydrochloride (Imipramine HCl) is a first generation tricyclic antidepressant that acts primarily as an inhibitor of serotonin and norepinephrine transporters (Kds = 1.4 and 37 nM, respectively).Imipramine hydrochloride is reported to prevent the translocation of aSMase, inhibiting MV and exosomes secretion

Imipramine hydrochloride

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Purity: 99.98%

Catalog No. T7941Alias Tofranil, Melipramine, Imipramine HCl, Imipramine (hydrochloride), G 22355Cas No. 113-52-0

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$30	In Stock	In Stock
50 mg	$39	In Stock	In Stock
100 mg	$53	In Stock	In Stock
500 mg	$118	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$57	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.98%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Imipramine hydrochloride AI Summary

Imipramine hydrochloride exhibits a multifaceted bioactivity profile. It shows significant antidepressant effects in various behavioral assays in mice, such as inhibiting tetrabenazine-induced depression of motor activity (ED50 = 0.58 mg/kg) and ptosis (ED50 = 0.98 mg/kg), and reducing immobility time in the forced swim test. The compound also inhibits the norepinephrine transporter with a Ki of 12.0 nM and demonstrates modest activity against serotonin uptake (Ki = 41.8 nM). In pharmacokinetic studies, Imipramine hydrochloride shows high protein binding affinity and consistent distribution ratios across species. It exhibits a bioavailability of 42.0%, a clearance rate of 13.0 mL/min/kg, and a half-life of 16.0 hours in humans. The compound's metabolism results in glucuronide concentrations in bile and urine, indicating substantial metabolic processing. Additionally, Imipramine hydrochloride exhibits antiplasmodial activity against various strains of Plasmodium falciparum, with IC50 values ranging from 1258.93 nM to 15848.93 nM. It also demonstrates antiviral properties, albeit with modest efficacy in inhibiting SARS-CoV-2-induced cytotoxicity in Caco-2 cells and inhibiting the SARS-CoV-2 3CL-Pro protease by 30.25% at 20µM. The compound also exhibits modest antifungal and antibacterial activities, with specific but low inhibition rates against Candida albicans, Cryptococcus neoformans, and different bacterial strains including Klebsiella pneumoniae and Staphylococcus aureus MRSA. Furthermore, Imipramine hydrochloride influences various cell types differently, inhibiting growth in HEK293T and human fibroblast cells but promoting growth in U2OS cells. The combined bioactivities and pharmacokinetic properties highlight the compound's potential for therapeutic applications across a range of conditions, including depression, infectious diseases, and central nervous system disorders..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Imipramine hydrochloride (Imipramine HCl) is a first generation tricyclic antidepressant that acts primarily as an inhibitor of serotonin and norepinephrine transporters (Kds = 1.4 and 37 nM, respectively).Imipramine hydrochloride is reported to prevent the translocation of aSMase, inhibiting MV and exosomes secretion
Targets&IC50	5-HT:32 nM (IC50)
Synonyms	Tofranil, Melipramine, Imipramine HCl, Imipramine (hydrochloride), G 22355

Chemical Properties

Molecular Weight	316.87
Formula	C₁₉H₂₅ClN₂
Cas No.	113-52-0
Smiles	CN(C)CCCN1c2ccccc2CCc2ccccc21.Cl
Relative Density.	1.041g/cm3

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (315.59 mM), Sonication is recommended.

H2O: 100 mg/mL (315.59 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (12.62 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	3.1559 mL	15.7793 mL	31.5587 mL	157.7934 mL
5 mM	0.6312 mL	3.1559 mL	6.3117 mL	31.5587 mL
10 mM	0.3156 mL	1.5779 mL	3.1559 mL	15.7793 mL
20 mM	0.1578 mL	0.7890 mL	1.5779 mL	7.8897 mL
50 mM	0.0631 mL	0.3156 mL	0.6312 mL	3.1559 mL
100 mM	0.0316 mL	0.1578 mL	0.3156 mL	1.5779 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc