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Anti-OLIG1 Antibody (5J665)
🥰Excellent
Catalog No. TMAB-09766
Antibody Type: Recombinant Rabbit Monoclonal
Application: WB
Reactivity: Human (predicted:Rat,Mouse)
Anti-OLIG1 Antibody (5J665)
Anti-OLIG1 Antibody (5J665)
🥰Excellent
Catalog No. TMAB-09766
Antibody Type: Recombinant Rabbit Monoclonal
Application: WB
Reactivity: Human (predicted:Rat,Mouse)
Application: WB
Reactivity: Human (predicted:Rat,Mouse)
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-OLIG1 Antibody (5J665) is a Rabbit antibody targeting OLIG1. Anti-OLIG1 Antibody (5J665) can be used in WB. |
| Ig Type | IgG |
| Clone | 5J665 |
| Reactivity | Human (predicted:Rat,Mouse) |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. |
| Tissue Specificity | Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas is highly variable. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The oligodendrocyte lineage-specific basic helix-loop-helix (OLIG) family of transcription factors include OLIG1-OLIG3, which differ in tissue expression. OLIG1 and OLIG2 are specifically expressed in nervous tissue as gene regulators of oligodendrogenesis. OLIG2 is more widely expressed in embryonic brain than OLIG1, while OLIG3 is primarily expressed in non-neural tissues. OLIG1 and OLIG2 interact with the Nkx-2.2 homeodomain protein, which is responsible for directing ventral neuronal patterning in response to graded Sonic hedgehog signaling in the embryonic neural tube. These interactions between OLIG proteins and Nkx-2.2 appear to promote the formation of alternate cell types by inhibiting V3 interneuron development. OLIG1 and OLIG2 are abundantly expressed in oligodendroglioma and nearly absent in astrocytomas. Therefore, OLIG proteins are candidates for molecular markers of human glial brain tumors, which are the most common primary malignancies of the human brain. |
| Immunogen | A synthesized peptide: human Oligo1 |
| Antigen Species | Human |
| Gene Name | OLIG1 |
| Gene ID | |
| Protein Name | Oligodendrocyte transcription factor 1 |
| Uniprot ID | |
| Function | romotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube (By similarity). |
| Molecular Weight | Theoretical: 28 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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