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Fluazinam

Name: Fluazinam
Brand: TargetMol
SKU: T5881
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5881Cas No. 79622-59-6

Fluazinam is a pyridinamine fungicide with a broad spectrum of antifungal activity and had a strong inhibition effect on mycelial growth of S. sclerotiorum populations.

Fluazinam

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Purity: 99.98%

Catalog No. T5881Cas No. 79622-59-6

Fluazinam is a pyridinamine fungicide with a broad spectrum of antifungal activity and had a strong inhibition effect on mycelial growth of S. sclerotiorum populations.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.98%

Color:Yellow

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COA HNMR LCMS

Product Introduction

Fluazinam AI Summary

Fluazinam exhibits a diverse range of bioactivities and fungicidal properties. As a bioactive compound, it functions as an agonist for multiple receptors and pathways including retinoid X receptor alpha, androgen receptor, glucocorticoid receptor, peroxisome proliferator-activated receptor gamma, nuclear factor-kappa B, Aryl hydrocarbon Receptor (AhR), antioxidant response element (ARE), p53, and rat pregnane X receptor (rPXR), and as an inhibitor for thyroid hormone receptor beta, farnesoid X receptor, Mammalian Selenoprotein Thioredoxin Reductase 1, Polymerase Iota, TGF-b, vitamin D receptor, estrogen receptor alpha, peroxisome proliferator-activated receptor delta, tyrosyl-DNA phosphodiesterase 1, alpha-syn inhibitors, Vaccinia Orthopoxvirus, and the Phosphatase Activity of Eya2. Regarding its fungicidal activities, Fluazinam effectively inhibits mycelial radial growth of Rhizoctonia solani AG-1 IA, with an EC50 of 0.046 ug/mL and an EC90 of 2.275 mg/L. It shows dose-dependent effects affecting mycelial growth from 3.4 mm to 9.1 mm at concentrations ranging from 0.1 mg/L to 100 mg/L. The compound is also active against Macrophomina phaseolina, with a fungicidal ED50 of 35.0 mg/kg in non-grafted Melon plants and an ED50 of less than 0.01 mg/kg for mycelial growth inhibition. Against Botryotinia fuckeliana, it prevents leaf lesions on cucumber seedlings and has a MIC of less than 16.0 ppm. Field trials indicate its activity on Kidney bean against Botryotinia fuckeliana with 7.8% activity at 500 ug/mL. Furthermore, Fluazinam demonstrates antifungal effects against Mycosphaerella nawae strains MY5 and MY1 on potato dextrose agar with EC50 values of 50.6 ug.mL-1 and 24.0 ug.mL-1, respectively. It also shows fungicidal properties against Podosphaera fuliginea on pre-treated cucumber plants with an IC90 of 63.0 ppm and against Magnaporthe oryzae on rice with an IC90 of less than 16.0 ppm..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Fluazinam is a pyridinamine fungicide with a broad spectrum of antifungal activity and had a strong inhibition effect on mycelial growth of S. sclerotiorum populations.

Chemical Properties

Molecular Weight	465.09
Formula	C₁₃H₄Cl₂F₆N₄O₄
Cas No.	79622-59-6
Smiles	N(C1=C(N(=O)=O)C(Cl)=C(C(F)(F)F)C=C1N(=O)=O)C2=C(Cl)C=C(C(F)(F)F)C=N2
Relative Density.	1.766 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (268.77 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (8.6 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1501 mL	10.7506 mL	21.5012 mL	107.5061 mL
5 mM	0.4300 mL	2.1501 mL	4.3002 mL	21.5012 mL
10 mM	0.2150 mL	1.0751 mL	2.1501 mL	10.7506 mL
20 mM	0.1075 mL	0.5375 mL	1.0751 mL	5.3753 mL
50 mM	0.0430 mL	0.2150 mL	0.4300 mL	2.1501 mL
100 mM	0.0215 mL	0.1075 mL	0.2150 mL	1.0751 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc