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NSC45586

🥰Excellent
Catalog No. T8985Cas No. 6300-44-3

NSC45586 is a protein phosphatase PHLPP inhibitor, which is selective for PHLPP1 and PHLPP2.

NSC45586

NSC45586

🥰Excellent
Purity: 99.31%
Catalog No. T8985Cas No. 6300-44-3
NSC45586 is a protein phosphatase PHLPP inhibitor, which is selective for PHLPP1 and PHLPP2.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$37In StockIn Stock
5 mg$58In StockIn Stock
10 mg$86In StockIn Stock
25 mg$146In StockIn Stock
50 mg$218In StockIn Stock
100 mg$347In StockIn Stock
200 mg$488-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:99.31%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
NSC45586 is a protein phosphatase PHLPP inhibitor, which is selective for PHLPP1 and PHLPP2.
Chemical Properties
Molecular Weight413.4
FormulaC20H18N6NaO3+
Cas No.6300-44-3
SmilesCC1=CC(=C(C=C1N)N)N=NC2=CC=C(C=C2)N=NC3=CC(=C(C=C3)O)C(=O)O.[Na+]
Relative Density.1.43g/cm3
ColorBlack
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: Insoluble
Ethanol: Insoluble
DMSO: 82 mg/mL (198.36 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4190 mL12.0948 mL24.1896 mL120.9482 mL
5 mM0.4838 mL2.4190 mL4.8379 mL24.1896 mL
10 mM0.2419 mL1.2095 mL2.4190 mL12.0948 mL
20 mM0.1209 mL0.6047 mL1.2095 mL6.0474 mL
50 mM0.0484 mL0.2419 mL0.4838 mL2.4190 mL
100 mM0.0242 mL0.1209 mL0.2419 mL1.2095 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PP2Cpleckstrin homology domain and leucine-rich repeat protein phosphatasePHLPP2PHLPP1PHLPPNSC-45586NSC45586NSC 45586InhibitorinhibitAKT
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