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Stauprimide
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Catalog No. T16941Cas No. 154589-96-5
Stauprimide is a non-broad spectrum inhibitor that binds to the MYC transcription factor NME2 and blocks its nuclear localization in ESCs, which causes down-regulation of MYC transcription.
Stauprimide
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Catalog No. T16941Cas No. 154589-96-5
Stauprimide is a non-broad spectrum inhibitor that binds to the MYC transcription factor NME2 and blocks its nuclear localization in ESCs, which causes down-regulation of MYC transcription.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 500 μg | $419 | 35 days | 35 days | |
| 1 mg | $419 | 35 days | 35 days | |
| 5 mg | $987 | 35 days | 35 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Stauprimide is a non-broad spectrum inhibitor that binds to the MYC transcription factor NME2 and blocks its nuclear localization in ESCs, which causes down-regulation of MYC transcription. |
| In vitro | Stauprimide (10 μM; 6 hours) inhibits MYC transcription in most cell lines tested (EC50: 30 nM-8 μM), reducing MYC levels by 15% to over 90%. At 5 μM for 3 hours, it suppresses MYC transcription by decreasing NME2 nuclear translocation, and at 2-8 μM for 24-72 hours, it down-regulates MYC, inhibiting cell proliferation in vitro (IC50: 780 nM in RXF 393 cells). Stauprimide (4-10 μM; 6 hours) exhibits various EC50s and degrees of MYC mRNA down-regulation across different cell lines [1]. |
| In vivo | Stauprimide (p.o.; 50 mg/kg; once daily; 30 days, 55 days) blocks tumor growth, decreases MYC protein levels in xenograft mouse with RXF 393 or CAKI-1 cells. It also inhibits MYC transcription in the RXF 393 tumor [1]. |
| Molecular Weight | 584.62 |
| Formula | C35H28N4O5 |
| Cas No. | 154589-96-5 |
| Smiles | COC1C(CC2OC1(C)n1c3ccccc3c3c4C(=O)NC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1 |
| Relative Density. | 1.52 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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