Home Tools
Log in
Cart

AKR1C3 Protein, Human, Recombinant (His)

Catalog No. TMPJ-00962
Synonyms: 3-Alpha-HSD Type 2, 17-β-Hydroxysteroid Dehydrogenase Type 5, Chlordecone Reductase Homolog HAKRb, Dihydrodiol Dehydrogenase, 17-Beta-Hydroxysteroid Dehydrogenase Type 5, 17-Beta-HSD 5, 17-β-HSD 5, 3-α-HSD Type II Brain, Aldo-Keto Reductase Family 1 Member C3, 3-α-Hydroxysteroid Dehydrogenase Type 2, 3-Alpha-Hydroxysteroid Dehydrogenase Type 2, 3-α-HSD Type 2, 3-Alpha-HSD Type II Brain

AKR1C3, is an enzyme which belongs to the aldo/keto reductase family. It is expressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate and testis. AKR1C3 catalyzes the conversion of aldehydes and ketones to alcohols. It catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2,which functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. It can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
AKR1C3 Protein, Human, Recombinant (His)
Pack Size Availability Price/USD Quantity
10 μg 5 days $ 184.00
50 μg 5 days $ 545.00
500 μg 5 days $ 1,900.00
1 mg 5 days $ 2,730.00
Bulk Inquiry
Get quote
Contact us for more batch information
Biological Description
Technical Params
Product Properties
Description AKR1C3, is an enzyme which belongs to the aldo/keto reductase family. It is expressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate and testis. AKR1C3 catalyzes the conversion of aldehydes and ketones to alcohols. It catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2,which functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. It can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites.
Species Human
Expression System Human Cells
Tag C-6His
Accession Number P42330
Synonyms 3-Alpha-HSD Type 2, 17-β-Hydroxysteroid Dehydrogenase Type 5, Chlordecone Reductase Homolog HAKRb, Dihydrodiol Dehydrogenase, 17-Beta-Hydroxysteroid Dehydrogenase Type 5, 17-Beta-HSD 5, 17-β-HSD 5, 3-α-HSD Type II Brain, Aldo-Keto Reductase Family 1 Member C3, 3-α-Hydroxysteroid Dehydrogenase Type 2, 3-Alpha-Hydroxysteroid Dehydrogenase Type 2, 3-α-HSD Type 2, 3-Alpha-HSD Type II Brain
Amino Acid Met1-Tyr323
Construction Recombinant Human Aldo-Keto Reductase Family 1 Member C3 is produced by our Mammalian expression system and the target gene encoding Met1-Tyr323 is expressed with a 6His tag at the C-terminus.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 38 KDa, reducing conditions
Endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 6% Sucrose, 2% Glycine, 100mM NaCl, 0.05% Tween 80,pH 6.0.
Reconstitution Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
Stability & Storage

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.

Research Background AKR1C3, is an enzyme which belongs to the aldo/keto reductase family. It is expressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate and testis. AKR1C3 catalyzes the conversion of aldehydes and ketones to alcohols. It catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2,which functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. It can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites.

Calculator

Reconstitution Calculator
Recombinant Proteins Dilute Calculator
Specific Activity Calculator
=
÷
X
=
X
(Unit/mg)
= 106 ÷
ng/mL

bottom

Tech Support

Please read the User Guide of Recombinant Proteins for more specific information.

Keywords

AKR1C3 Protein, Human, Recombinant (His) 3-Alpha-HSD Type 2 3-a-HSD Type II Brain 17-β-Hydroxysteroid Dehydrogenase Type 5 Chlordecone Reductase Homolog HAKRb Dihydrodiol Dehydrogenase 17-Beta-Hydroxysteroid Dehydrogenase Type 5 17-Beta-HSD 5 17-β-HSD 5 17-b-Hydroxysteroid Dehydrogenase Type 5 3-a-HSD Type 2 3-α-HSD Type II Brain 17-b-HSD 5 Aldo-Keto Reductase Family 1 Member C3 3-α-Hydroxysteroid Dehydrogenase Type 2 3-a-Hydroxysteroid Dehydrogenase Type 2 3-Alpha-Hydroxysteroid Dehydrogenase Type 2 3-α-HSD Type 2 3-Alpha-HSD Type II Brain recombinant recombinant-proteins proteins protein

 

TargetMol