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Vonoprazan

Name: Vonoprazan
Brand: TargetMol
SKU: T8388
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8388Cas No. 881681-00-1

Alias TAK-438 (free base)

Vonoprazan (TAK-438 (free base)) is an orally active potassium-competitive acid blocker.Vonoprazan can be used for the treatment of gastroduodenal ulcer and reflux esophagitis

Vonoprazan

🥰Excellent

Purity: 99.92%

Catalog No. T8388Alias TAK-438 (free base)Cas No. 881681-00-1

Vonoprazan (TAK-438 (free base)) is an orally active potassium-competitive acid blocker.Vonoprazan can be used for the treatment of gastroduodenal ulcer and reflux esophagitis

Pack Size	Price	Availability	Quantity
50 mg	$29	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Batch Information

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Purity:99.92%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Vonoprazan (TAK-438 (free base)) is an orally active potassium-competitive acid blocker.Vonoprazan can be used for the treatment of gastroduodenal ulcer and reflux esophagitis
Targets&IC50	H+, K+ ATPase (porcine gastric, at pH 6.5):19 nM (IC50)
Synonyms	TAK-438 (free base)

Chemical Properties

Molecular Weight	345.39
Formula	C₁₇H₁₆FN₃O₂S
Cas No.	881681-00-1
Smiles	CNCc1cc(-c2ccccc2F)n(c1)S(=O)(=O)c1cccnc1
Relative Density.	1.31 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (289.53 mM), Heating is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8953 mL	14.4764 mL	28.9528 mL	144.7639 mL
5 mM	0.5791 mL	2.8953 mL	5.7906 mL	28.9528 mL
10 mM	0.2895 mL	1.4476 mL	2.8953 mL	14.4764 mL
20 mM	0.1448 mL	0.7238 mL	1.4476 mL	7.2382 mL
50 mM	0.0579 mL	0.2895 mL	0.5791 mL	2.8953 mL
100 mM	0.0290 mL	0.1448 mL	0.2895 mL	1.4476 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc