Powder: -20°C for 3 years | In solvent: -80°C for 1 year
hCAIX-IN-12 is an effective hCAIX inhibitor, IC50 for CAIX and CAII is 0.74 and 10.78 μM , respectively. hCAIX-IN-12 inhibits cell proliferation and induces apoptosis. HCAIX-IN-12 can increase the generation of ROS. HCAIX-IN-12 has research potential in colorectal cancer (CRC).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | hCAIX-IN-12 is an effective hCAIX inhibitor, IC50 for CAIX and CAII is 0.74 and 10.78 μM , respectively. hCAIX-IN-12 inhibits cell proliferation and induces apoptosis. HCAIX-IN-12 can increase the generation of ROS. HCAIX-IN-12 has research potential in colorectal cancer (CRC). |
In vitro | hCAIX-IN-12 (compound OX27) demonstrates antiproliferative effects on HCT-116 cells, achieving an IC50 value of 6.0 μM [1]. It notably reduces CAIX expression levels in these cells, with its inhibitory effect being more significant under hypoxic conditions [1]. Additionally, hCAIX-IN-12 inhibits HCT-116 cell colony formation and migration in a dose- and time-dependent manner, suggesting dose-dependent efficacy [1]. At a concentration of 6.0 μM and exposure times of 24 and 48 hours, it triggers apoptosis and leads to an increase in reactive oxygen species (ROS) levels within HCT-116 cells [1]. Moreover, hCAIX-IN-12 disrupts the cell cycle, causing a decrease in the G0/G1 phase population (65.21%) and an accumulation of cells in the G2/M phase (18.95%) [1]. It exhibits a high binding affinity to CAIX and significant affinity to human serum albumin (HSA) [1]. |
Molecular Weight | 398.46 |
Formula | C18H14N4O3S2 |
CAS No. | 2414598-85-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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hCAIX-IN-12 2414598-85-7 inhibitor inhibit