LRP-6 Protein, Human, Recombinant (mFc)

Name: LRP-6 Protein, Human, Recombinant (mFc)
Brand: TargetMol
SKU: TMPK-00744
Rating: 4.5 (1 reviews)

(Synonyms: LRP-6, LRP6, FLJ90421, FLJ90062, DCAD2) Copy Product Info

Synonyms: LRP-6, LRP6, FLJ90421, FLJ90062, DCAD2

Catalog No. TMPK-00744 Copy Product Info

Low-density lipoprotein receptor protein 6 (LRP6) is a Wnt co-receptor with essential functions in the Wnt/β-catenin pathway, and mutations in LRP6 gene are linked to many complex human diseases, including metabolic syndrome, cancer, Alzheimer's disease and osteoporosis. LRP-6 interacts closely with PDGF receptor β and TGF-β receptor 1 at the cell membrane, suggesting that it may have roles in pathways other than WNT/β-catenin. LRP-6 Protein, Human, Recombinant (mFc) is expressed in HEK293 Cells. The accession number is O75581-1.

Pack Size	Price	USA Stock	Global Stock
10 µg	$72	7-10 days	7-10 days
20 µg	$115	7-10 days	7-10 days
50 µg	$222	7-10 days	7-10 days
100 µg	$371	7-10 days	7-10 days
200 µg	$673	7-10 days	7-10 days
500 µg	$1,490	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Cart

Add to Quotation

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Resource Download

User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Immobilized Human DKK1, His Tag at 5 μg/mL (100 μL/well) on the plate. Dose response curve for Human LRP-6, mFc Tag with the EC50 of 0.58 μg/mL determined by ELISA. Immobilized Human SOST, His Tag at 2 μg/mL (100 μL/well) on the plate. Dose response curve for Human LRP-6, mFc Tag with the EC50 of 13.1 ng/mL determined by ELISA. Immobilized Human LRP-6, mFc Tag at 5 μg/mL (100 μL/well) on the plate. Dose response curve for Human R spondin 1, His Tag with the EC50 of 4.4 μg/mL determined by ELISA.
Description	Low-density lipoprotein receptor protein 6 (LRP6) is a Wnt co-receptor with essential functions in the Wnt/β-catenin pathway, and mutations in LRP6 gene are linked to many complex human diseases, including metabolic syndrome, cancer, Alzheimer's disease and osteoporosis. LRP-6 interacts closely with PDGF receptor β and TGF-β receptor 1 at the cell membrane, suggesting that it may have roles in pathways other than WNT/β-catenin. LRP-6 Protein, Human, Recombinant (mFc) is expressed in HEK293 Cells. The accession number is O75581-1.
Species	Human
Expression System	HEK293 Cells
Tag	C-mFc (IgG2a)
Accession Number	O75581-1
Construction	Ala20-Pro630
Protein Purity	> 90% as determined by Tris-Bis PAGE
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Supplied as 0.22 μm filtered solution in PBS (pH 7.4).
Synonyms	LRP-6, LRP6, FLJ90421, FLJ90062, DCAD2
Research Background	Low-density lipoprotein receptor protein 6 (LRP6) is a Wnt co-receptor with essential functions in the Wnt/β-catenin pathway, and mutations in LRP6 gene are linked to many complex human diseases, including metabolic syndrome, cancer, Alzheimer's disease and osteoporosis. LRP-6 interacts closely with PDGF receptor β and TGF-β receptor 1 at the cell membrane, suggesting that it may have roles in pathways other than WNT/β-catenin.

Chemical Properties

Molecular Weight

95.32 kDa (predicted); 97-110 kDa (Bis-Tris PAGE, due to glycosylation)

Storage & Solubility Information

Shipping	Proteins are shipped with blue ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.