EZH2-IN-5

Name: EZH2-IN-5
Brand: TargetMol
SKU: T38827
Rating: 4.5 (1 reviews)

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Catalog No. T38827Cas No. 1403258-69-4

Alias EZH2-IN-5

EZH2-IN-5 is a highly effective inhibitor of EZH2, displaying remarkable potency against both wild-type and mutant Tyr641 EZH2, with IC50 values of 1.52 nM and 4.07 nM, respectively.

EZH2-IN-5

😃Good

Catalog No. T38827Alias EZH2-IN-5Cas No. 1403258-69-4

EZH2-IN-5 is a highly effective inhibitor of EZH2, displaying remarkable potency against both wild-type and mutant Tyr641 EZH2, with IC50 values of 1.52 nM and 4.07 nM, respectively.

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5 mg	$970	Inquiry	Inquiry

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Product Introduction

Bioactivity

Description	EZH2-IN-5 is a highly effective inhibitor of EZH2, displaying remarkable potency against both wild-type and mutant Tyr641 EZH2, with IC50 values of 1.52 nM and 4.07 nM, respectively.
Targets&IC50	EZH2 (WT):1.52 nM (IC50), EZH2 (Y641F):4.07 nM (IC50)
In vitro	EZH2-IN-5 (compound 276) effectively suppresses the proliferation of WSUDLCL2 cell lines, with an inhibitory concentration (IC50) of 187.28 nM[1].
Synonyms	EZH2-IN-5

Chemical Properties

Molecular Weight	517.512
Formula	C₂₆H₃₇BrN₄O₂
Cas No.	1403258-69-4
Smiles	CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(Br)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C \|wU:3.2,wD:6.9,(,1.54,;;-1.33,-.77,;-2.67,,;-4,-.77,;-5.33,,;-5.33,1.54,;-4,2.31,;-2.67,1.54,;-6.67,2.31,;-8,1.54,;-6.67,3.85,;-1.33,-2.31,;-2.67,-3.08,;-2.67,-4.62,;-4,-5.39,;-1.33,-5.39,;,-4.62,;1.33,-5.39,;2.67,-4.62,;1.33,-6.93,;2.67,-7.7,;2.67,-9.24,;4,-10.01,;5.33,-9.24,;4,-11.55,;2.67,-12.32,;2.67,-13.86,;1.33,-11.55,;1.33,-10.01,;,-9.24,;,-3.08,;1.33,-2.31,)\|

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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