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MT189

🥰Excellent
Catalog No. T60129Cas No. 1885900-35-5
Alias Antiproliferative agent-14

MT189 (Antiproliferative agent-14) is a potent tubulin polymerization inhibitor, with an IC50 of 3.41 μM. Antiproliferative agent-14 has excellent antiproliferative activity. Antiproliferative agent-14 possess the ability to arrest cells at G2/M phases of the cell cycle.

MT189

MT189

🥰Excellent
Purity: 98.52%
Catalog No. T60129Alias Antiproliferative agent-14Cas No. 1885900-35-5
MT189 (Antiproliferative agent-14) is a potent tubulin polymerization inhibitor, with an IC50 of 3.41 μM. Antiproliferative agent-14 has excellent antiproliferative activity. Antiproliferative agent-14 possess the ability to arrest cells at G2/M phases of the cell cycle.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$31-In Stock
5 mg$53-In Stock
10 mg$82-In Stock
25 mg$166-In Stock
50 mg$238-In Stock
100 mg$350-In Stock
200 mg$479-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:98.52%
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Product Introduction

Bioactivity
Description
MT189 (Antiproliferative agent-14) is a potent tubulin polymerization inhibitor, with an IC50 of 3.41 μM. Antiproliferative agent-14 has excellent antiproliferative activity. Antiproliferative agent-14 possess the ability to arrest cells at G2/M phases of the cell cycle.
In vitro
MT189 shows antiproliferative activity against HeLa cell (IC50=13 nM). Antiproliferative agent-14 shows inhibition of colchicine binding activity, with 72.2% inhibitory percentage[1].
SynonymsAntiproliferative agent-14
Chemical Properties
Molecular Weight363.38
FormulaC21H18FN3O2
Cas No.1885900-35-5
SmilesCOc1ccc(CNc2c(nc3ccc(F)cn23)-c2ccccc2O)cc1
Relative Density.1.28 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 90 mg/mL (247.67 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7519 mL13.7597 mL27.5194 mL137.5970 mL
5 mM0.5504 mL2.7519 mL5.5039 mL27.5194 mL
10 mM0.2752 mL1.3760 mL2.7519 mL13.7597 mL
20 mM0.1376 mL0.6880 mL1.3760 mL6.8799 mL
50 mM0.0550 mL0.2752 mL0.5504 mL2.7519 mL
100 mM0.0275 mL0.1376 mL0.2752 mL1.3760 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

MT-189MT189MT 189MicrotubuleAssociatedMicrotubule/TubulinMicrotubule Associated
Related Tags: buy MT189 | purchase MT189 | MT189 cost | order MT189 | MT189 chemical structure | MT189 in vitro | MT189 formula | MT189 molecular weight
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