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Anti-SIGIRR Antibody (6K128)

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Catalog No. TMAY-02261
Alias TIR8, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

Anti-SIGIRR Antibody (6K128) is a Rabbit antibody targeting SIGIRR. Anti-SIGIRR Antibody (6K128) can be used in FCM.

Anti-SIGIRR Antibody (6K128)

Anti-SIGIRR Antibody (6K128)

😃Good
Catalog No. TMAY-02261Alias TIR8, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
Anti-SIGIRR Antibody (6K128) is a Rabbit antibody targeting SIGIRR. Anti-SIGIRR Antibody (6K128) can be used in FCM.
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100 μL$268 7-10 days
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Product Introduction

Bioactivity
Description
Anti-SIGIRR Antibody (6K128) is a Rabbit antibody targeting SIGIRR. Anti-SIGIRR Antibody (6K128) can be used in FCM.
AliasTIR8, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
Ig Type
Monoclonal Rabbit IgG
Clone
6K128
Reactivity
Human
Verified Activity
Flow cytometric analysis of Human SIGIRR expression on SW480 cells. Cells were stained with purified anti-Human SIGIRR, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Application
FCM
Recommended Dose
FCM: 1:25-1:100
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionThis antibody was obtained from a rabbit immunized with purified, recombinant Human SIGIRR / TIR8 (rh SIGIRR / TIR8; TMPY-01894; Q6IA17-1; Met1-His118).
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundSingle Ig IL-1-related receptor (SIGIRR) or TIR8 is a member of Toll-like receptor-interleukin 1 receptor signaling (TLR-IL-1R) receptor superfamily. Although SIGIRR/TIR8 shows the typical conserved motifs that characterize the IL-1R and Toll superfamily, it is structurally and functionally distinct from both. SIGIRR/TIR8 has only one Ig domain in its extracellular portion whereas the IL-1R family contains three Ig folds. An unusually long cytoplasmic domain is reminiscent of the structure of drosophila Toll, yet the SIGIRR peptide sequence is more closely related to IL-1RI. SIGIRR/TIR8 was mainly expressed in mouse and human epithelial tissues such as kidney, lung and gut. Resting and activated T and B lymphocytes and monocytes-macrophages expressed little or no SIGIRR/TIR8, with the exception of the mouse GG2EE macrophage line. Inflammation is enhanced in SIGIRR-deficient mice. SIGIRR negatively modulates immune responses. Inflammation is enhanced in SIGIRR-deficient mice, as shown by their enhanced chemokine induction after IL-1 injection and reduced threshold for lethal endotoxin challenge.
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
PE
Antibody Types Available
2
Antigen Details
Immunogen
Recombinant Human SIGIRR/TIR8 Protein (TMPY-01894)
Antigen Species
Human
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

Sci Citations

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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