Anti-CSNK1G2 Antibody (2Y967) is a Rabbit antibody targeting CSNK1G2. Anti-CSNK1G2 Antibody (2Y967) can be used in WB,ICC/IF,FCM.

IgG

2Y967

Human (predicted:Mouse,Rat)

Blocking buffer: 5% NFDM/TBST
Primary Ab dilution: 1:5000
Primary Ab incubation condition: 2 hours at room temperature
Secondary Ab: Goat Anti-Rabbit IgG H&L (HRP)
Lysate: 1: HeLa, 2: 4T1, 3: RAW 264.7, 4: Rat brain
Protein loading quantity: 20 μg
Exposure time: 60 s
Predicted MW: 50 kDa
Observed MW: 50 kDa

WB: 1:500-2000; ICC/IF: 1:50-100; FCM: 1:50-100

Monoclonal

KLH conjugated synthetic peptide: human CSNK1G2

Human

CSNK1G2

Casein kinase I isoform gamma-2

Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis.