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Anti-LC3B Antibody (7R171)
😃Good
Catalog No. TMAB-08239
Anti-LC3B Antibody (7R171) is a Rabbit antibody targeting LC3B. Anti-LC3B Antibody (7R171) can be used in IHC-P,IHC-Fr,IF,WB.
Anti-LC3B Antibody (7R171)
Anti-LC3B Antibody (7R171)
😃Good
Catalog No. TMAB-08239
Anti-LC3B Antibody (7R171) is a Rabbit antibody targeting LC3B. Anti-LC3B Antibody (7R171) can be used in IHC-P,IHC-Fr,IF,WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $151 | 7-10 days | 7-10 days | |
| 50 μL | $261 | 7-10 days | 7-10 days | |
| 100 μL | $472 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-LC3B Antibody (7R171) is a Rabbit antibody targeting LC3B. Anti-LC3B Antibody (7R171) can be used in IHC-P,IHC-Fr,IF,WB. |
| Ig Type | IgG/Kappa |
| Clone | 7R171 |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | IHC-P: 1:50-200; IHC-Fr: 1:50-200; IF: 1:50-200; WB: 1:500-2000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasmic. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Note: LC3B binds to the autophagic membranes. |
| Tissue Specificity | Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | A major contributor to cellular homeostasis is the ability of the cell to strike a balance between the formation and degradation/removal of its cellular components. This process of internal cellular turn-over is called autophagy (self-eating), and is facilitated by a pathway of around 16 interacting proteins in the human. LC3, a ubiquitin-like modifier protein, is the human homolog of yeast Apg8 and is involved in the formation of autophagosomal vacuoles, called autophagosomes. LC3 is expressed as 3 splice variants (LC3A, LC3B and LC3C), which exhibit different tissue distributions and are processed into cytosolic and autophagosomal membrane-bound forms, termed LC3-I and LC3-II, respectively. A disruption to the autophagic process is now associated with the progression of several cancers, neurodegenerative disorders and cardiac pathologies, where LC3 is widely employed as a marker for autophagy. |
| Immunogen | A synthesized peptide: human LC3B |
| Antigen Species | Human |
| Gene Name | MAP1LC3B |
| Gene ID | |
| Protein Name | Microtubule-associated proteins 1A/1B light chain 3B |
| Uniprot ID | |
| Function | Probably involved in formation of autophagosomal vacuoles (autophagosomes). |
| Molecular Weight | Theoretical: 15 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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