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11β-HSD1 inibitor 19

Name: 11β-HSD1 inibitor 19
Brand: TargetMol
SKU: T72022
Price: 147 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T72022Cas No. 946400-19-7

11β-HSD1 inibitor 19 shows inhibitory activities for hHSD1 and mHSD1 with IC50s of 16 nM and 10 nM.

11β-HSD1 inibitor 19

🥰Excellent

Purity: 99.35%

Catalog No. T72022Cas No. 946400-19-7

11β-HSD1 inibitor 19 shows inhibitory activities for hHSD1 and mHSD1 with IC50s of 16 nM and 10 nM.

Pack Size	Price	Availability
1 mg	$147	In Stock
5 mg	$348	In Stock
10 mg	$475	In Stock
25 mg	$667	In Stock
50 mg	$826	In Stock
100 mg	$1,050	In Stock
200 mg	$1,370	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.35%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	11β-HSD1 inibitor 19 shows inhibitory activities for hHSD1 and mHSD1 with IC50s of 16 nM and 10 nM.
Targets&IC50	HSD1 (mouse):10 nM, HSD1 (human):16 nM

Chemical Properties

Molecular Weight	461.86
Formula	C₁₉H₁₆ClF₄N₃O₂S
Cas No.	946400-19-7
Smiles	C(F)(F)(F)C1=C(N2C[C@@H](C)N(S(=O)(=O)C3=C(Cl)C=C(C#N)C=C3)CC2)C=CC(F)=C1
Relative Density.	1.52 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (119.08 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1652 mL	10.8258 mL	21.6516 mL	108.2579 mL
5 mM	0.4330 mL	2.1652 mL	4.3303 mL	21.6516 mL
10 mM	0.2165 mL	1.0826 mL	2.1652 mL	10.8258 mL
20 mM	0.1083 mL	0.5413 mL	1.0826 mL	5.4129 mL
50 mM	0.0433 mL	0.2165 mL	0.4330 mL	2.1652 mL
100 mM	0.0217 mL	0.1083 mL	0.2165 mL	1.0826 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc