Shopping Cart

Your shopping cart is currently empty

11β-HSD1 inibitor 19

Name: 11β-HSD1 inibitor 19
Brand: TargetMol
SKU: T72022
Price: 147 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T72022Cas No. 946400-19-7

11β-HSD1 inibitor 19 shows inhibitory activities for hHSD1 and mHSD1 with IC50s of 16 nM and 10 nM.

11β-HSD1 inibitor 19

Copy Product Info

😃Good

Purity: 99.58%

Catalog No. T72022Cas No. 946400-19-7

11β-HSD1 inibitor 19 shows inhibitory activities for hHSD1 and mHSD1 with IC50s of 16 nM and 10 nM.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$147	In Stock	In Stock
5 mg	$348	In Stock	In Stock
10 mg	$475	In Stock	In Stock
25 mg	$667	In Stock	In Stock
50 mg	$826	In Stock	In Stock
100 mg	$1,050	In Stock	In Stock
200 mg	$1,370	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.58%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

11β-HSD1 inibitor 19 AI Summary

11β-HSD1 inibitor 19 shows potent inhibition of human and mouse 11betaHSD1 enzymes with IC50 values of 16.0 nM and 10.0 nM, respectively. However, its activity decreases significantly in the presence of 10% human serum, with an IC50 of 398.0 nM. The compound exhibits moderate metabolic stability in both mouse liver microsomes (T1/2 = 0.2167 hr) and human liver microsomes (T1/2 = 0.2333 hr)..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	11β-HSD1 inibitor 19 shows inhibitory activities for hHSD1 and mHSD1 with IC50s of 16 nM and 10 nM.
Targets&IC50	HSD1 (human):16 nM, HSD1 (mouse):10 nM

Chemical Properties

Molecular Weight	461.86
Formula	C₁₉H₁₆ClF₄N₃O₂S
Cas No.	946400-19-7
Smiles	C(F)(F)(F)C1=C(N2C[C@@H](C)N(S(=O)(=O)C3=C(Cl)C=C(C#N)C=C3)CC2)C=CC(F)=C1
Relative Density.	1.52 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (119.08 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1652 mL	10.8258 mL	21.6516 mL	108.2579 mL
5 mM	0.4330 mL	2.1652 mL	4.3303 mL	21.6516 mL
10 mM	0.2165 mL	1.0826 mL	2.1652 mL	10.8258 mL
20 mM	0.1083 mL	0.5413 mL	1.0826 mL	5.4129 mL
50 mM	0.0433 mL	0.2165 mL	0.4330 mL	2.1652 mL
100 mM	0.0217 mL	0.1083 mL	0.2165 mL	1.0826 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc