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Amiloride hydrochloride dihydrate

🥰Excellent
Catalog No. T0175LCas No. 17440-83-4
Alias MK-870 hydrochloride dihydrate, Amiloride HCl dihydrate

Amiloride hydrochloride dihydrate (Amiloride HCl dihydrate) is a pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride hydrochloride dihydrate is used in conjunction with DIURETICS to spare POTASSIUM loss.

Amiloride hydrochloride dihydrate
Other Forms of Amiloride hydrochloride dihydrate:
Amiloride hydrochlorideT01752016-88-8
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Amiloride hydrochloride dihydrate

🥰Excellent
Purity: 99.07%
Catalog No. T0175LAlias MK-870 hydrochloride dihydrate, Amiloride HCl dihydrateCas No. 17440-83-4
Amiloride hydrochloride dihydrate (Amiloride HCl dihydrate) is a pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride hydrochloride dihydrate is used in conjunction with DIURETICS to spare POTASSIUM loss.
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1 mL x 10 mM (in DMSO)$29-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:99.07%
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Product Introduction

Bioactivity
Description
Amiloride hydrochloride dihydrate (Amiloride HCl dihydrate) is a pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride hydrochloride dihydrate is used in conjunction with DIURETICS to spare POTASSIUM loss.
In vivo
Amiloride inhibits autophosphorylation of the EGF receptor and induces dephosphorylation of phosphoinositide 3-kinase, phosphoinositide-dependent kinase-1, PTEN (phosphatase and tensin homolog deleted on chromosome ten), and PP1 alpha phosphatase. It also blocks the adhesion of HL-60 cells induced by phorbol ester (where adhesion indicates a differentiated state), unlike dimethylamiloride (and EIPA, another Amiloride-like effective drug). In intact rabbit proximal tubules, Amiloride reduces oxygen consumption sensitive to ouabain in the presence of extracellular sodium at varying concentrations.
SynonymsMK-870 hydrochloride dihydrate, Amiloride HCl dihydrate
Chemical Properties
Molecular Weight302.12
FormulaC6H8ClN7O·HCl·2H2O
Cas No.17440-83-4
SmilesNC(N)=NC(=O)c1nc(Cl)c(N)nc1N
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: 17 mg/mL (56.27 mM), Sonication is recommended.
DMSO: 25 mg/mL (82.75 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.62 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM3.3099 mL16.5497 mL33.0994 mL165.4972 mL
5 mM0.6620 mL3.3099 mL6.6199 mL33.0994 mL
10 mM0.3310 mL1.6550 mL3.3099 mL16.5497 mL
20 mM0.1655 mL0.8275 mL1.6550 mL8.2749 mL
50 mM0.0662 mL0.3310 mL0.6620 mL3.3099 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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%
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TRPVChannelTRPV ChannelTRPChannelTRP ChannelTransient receptor potential channelsSodiumChannelSodium ChannelNa+ channelsNa channelsMK-870 hydrochloride DihydrateMK-870 HydrochlorideMK870 HydrochlorideMK 870 HydrochlorideInhibitorinhibitApoptosisAmiloride-sensitive sodium channelAmiloride hydrochloride DihydrateAmiloride hydrochloride dihydrateAmiloride HydrochlorideAmiloride HCl DihydrateAmiloride HCl
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