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Amiloride hydrochloride dihydrate

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Catalog No. T0175LCas No. 17440-83-4
Alias MK-870 hydrochloride dihydrate, Amiloride HCl dihydrate

Amiloride hydrochloride dihydrate (Amiloride HCl dihydrate) is a pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride hydrochloride dihydrate is used in conjunction with DIURETICS to spare POTASSIUM loss.

Amiloride hydrochloride dihydrate
Other Forms of Amiloride hydrochloride dihydrate:

Amiloride hydrochloride dihydrate

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Purity: 99.07%
Catalog No. T0175LAlias MK-870 hydrochloride dihydrate, Amiloride HCl dihydrateCas No. 17440-83-4
Amiloride hydrochloride dihydrate (Amiloride HCl dihydrate) is a pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride hydrochloride dihydrate is used in conjunction with DIURETICS to spare POTASSIUM loss.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mL x 10 mM (in DMSO)$29-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.07%
Color:White
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Product Introduction

Bioactivity
Description
Amiloride hydrochloride dihydrate (Amiloride HCl dihydrate) is a pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride hydrochloride dihydrate is used in conjunction with DIURETICS to spare POTASSIUM loss.
In vivo
Amiloride inhibits autophosphorylation of the EGF receptor and induces dephosphorylation of phosphoinositide 3-kinase, phosphoinositide-dependent kinase-1, PTEN (phosphatase and tensin homolog deleted on chromosome ten), and PP1 alpha phosphatase. It also blocks the adhesion of HL-60 cells induced by phorbol ester (where adhesion indicates a differentiated state), unlike dimethylamiloride (and EIPA, another Amiloride-like effective drug). In intact rabbit proximal tubules, Amiloride reduces oxygen consumption sensitive to ouabain in the presence of extracellular sodium at varying concentrations.
SynonymsMK-870 hydrochloride dihydrate, Amiloride HCl dihydrate
Chemical Properties
Molecular Weight302.12
FormulaC6H8ClN7O·HCl·2H2O
Cas No.17440-83-4
SmilesNC(N)=NC(=O)c1nc(Cl)c(N)nc1N
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: 17 mg/mL (56.27 mM), Sonication is recommended.
DMSO: 25 mg/mL (82.75 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.62 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM3.3099 mL16.5497 mL33.0994 mL165.4972 mL
5 mM0.6620 mL3.3099 mL6.6199 mL33.0994 mL
10 mM0.3310 mL1.6550 mL3.3099 mL16.5497 mL
20 mM0.1655 mL0.8275 mL1.6550 mL8.2749 mL
50 mM0.0662 mL0.3310 mL0.6620 mL3.3099 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TRPVChannelTRPV ChannelTRPChannelTRP ChannelTransient receptor potential channelsSodiumChannelSodium ChannelNa+ channelsNa channelsMK-870 hydrochloride DihydrateMK-870 HydrochlorideMK870 HydrochlorideMK 870 HydrochlorideInhibitorinhibitApoptosisAmiloride-sensitive sodium channelAmiloride hydrochloride DihydrateAmiloride HydrochlorideAmiloride HCl DihydrateAmiloride HCl
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