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Alrestatin
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Catalog No. T5195Cas No. 51411-04-2
Alias AY-22284
Alrestatin (AY-22284) is a specific inhibitor of aldose reductase and attenuates glucose-induced angiotensin II production in rat vascular smooth muscle in vitro.
Alrestatin
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Purity: 99.23%
Catalog No. T5195Alias AY-22284Cas No. 51411-04-2
Alrestatin (AY-22284) is a specific inhibitor of aldose reductase and attenuates glucose-induced angiotensin II production in rat vascular smooth muscle in vitro.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $31 | In Stock | In Stock | |
| 10 mg | $53 | In Stock | In Stock | |
| 25 mg | $92 | In Stock | In Stock | |
| 50 mg | $119 | In Stock | In Stock | |
| 100 mg | $197 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $35 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.23%
Appearance:Solid
Color:White
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Product Introduction
Alrestatin AI Summary
Alrestatin exhibits a broad spectrum of bioactivities, notably as an inhibitor of aldose reductase with variable potencies across different sources and experimental conditions. It shows inhibitory activity against calf lens aldose reductase, human placental aldose reductase, and rat lens aldose reductase with IC50 values ranging from 10E-5 to 34000.0 nM depending on the assay conditions. In various models, it has demonstrated the capacity to reduce sorbitol and galactitol levels in the sciatic nerve in both streptozotocinized and galactosemic rats with ED50 values between 0.000001 and 1000 mg kg-1 day-1. Additionally, it exhibits inhibitory activities against other targets such as Menin-MLL interaction, HSD17B4, Tau fibril formation, 15-hLO, RGS4, and SARS-CoV-2 with varying potencies. The compound also shows moderate liver toxicity in clinical settings, affecting 11.1% of cases, but does not present with acute or severe chronic liver conditions. This profile suggests that Alrestatin is a multifunctional bioactive agent with significant potential in targeting various biological pathways and diseases..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Alrestatin (AY-22284) is a specific inhibitor of aldose reductase and attenuates glucose-induced angiotensin II production in rat vascular smooth muscle in vitro. |
| Synonyms | AY-22284 |
| Molecular Weight | 255.2256 |
| Formula | C14H9NO4 |
| Cas No. | 51411-04-2 |
| Smiles | OC(=O)CN1C(=O)c2cccc3cccc(C1=O)c23 |
| Relative Density. | 1.511g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 25 mg/mL (97.95 mM), Sonication is recommended.  H2O: Insoluble | ||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.84 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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