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Anti-SECTM1 Antibody (4V578)
😃Good
Catalog No. TMAY-02303
Alias secreted and transmembrane 1, K12
Anti-SECTM1 Antibody (4V578) is a Rabbit antibody targeting SECTM1. Anti-SECTM1 Antibody (4V578) can be used in ELISA.
Anti-SECTM1 Antibody (4V578)
Anti-SECTM1 Antibody (4V578)
😃Good
Catalog No. TMAY-02303Alias secreted and transmembrane 1, K12
Anti-SECTM1 Antibody (4V578) is a Rabbit antibody targeting SECTM1. Anti-SECTM1 Antibody (4V578) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $269 | 7-10 days |
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Product Introduction
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Antigen Details
Chemical Properties
| Description | Anti-SECTM1 Antibody (4V578) is a Rabbit antibody targeting SECTM1. Anti-SECTM1 Antibody (4V578) can be used in ELISA. |
| Alias | secreted and transmembrane 1, K12 |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 4V578 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human SECTM1 (rh SECTM1; TMPY-02045; Q8WVN6-1; Met1-Gly145). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Secreted and transmembrane 1 (SECTM1), also known as K12, is a transmembrane and secreted protein with characteristics of a type 1a transmembrane protein of SECTM family. It is found in a perinuclear Golgi-like pattern and thought to be involved in hematopoietic and/or immune system processes. The human K12 protein has been shown to be primarily expressed in spleen, prostate, testis, small intestine, and in peripheral blood leukocytes. The K12 protein is expressed on the cell surface in such small amounts as to preclude detection. Alternatively, it may be that K12 on the cell surface is rapidly cleaved to generate a soluble K12 protein. Immunohistochemical analysis of peripheral blood cells shows that K12 is found in leukocytes of the myeloid lineage, with the strongest staining observed in granulocytes and no detectable expression in lymphocytes. May be involved in thymocyte signaling. It had been suggested a role for thymic microenvironment-produced K12 in regulation of thymocyte signaling and cytokine release, particularly in the setting of thymus pathology where IFN-gamma is upregulated such as myasthenia gravis. In addition, as a putative natural CD7 ligand, SECTM1/K12 may be responsible for the costimulatory role it plays in T cell activation. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human SECTM1 Protein (TMPY-02045) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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