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Thienopyridone
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Catalog No. T13146Cas No. 1018454-97-1
Thienopyridone is a potent and selective inhibitor of phosphatase of regenerating liver (PRL) phosphatase [IC50 values of 173 nM for PRL-1, 277 nM for PRL-2, and 128 nM for PRL-3], and induces p130Cas cleavage and apoptosis with anticancer effects.
Thienopyridone
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Catalog No. T13146Cas No. 1018454-97-1
Thienopyridone is a potent and selective inhibitor of phosphatase of regenerating liver (PRL) phosphatase [IC50 values of 173 nM for PRL-1, 277 nM for PRL-2, and 128 nM for PRL-3], and induces p130Cas cleavage and apoptosis with anticancer effects.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $767 | 6-8 weeks | 6-8 weeks | |
| 50 mg | $997 | 6-8 weeks | 6-8 weeks | |
| 100 mg | $1,540 | 6-8 weeks | 6-8 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Thienopyridone is a potent and selective inhibitor of phosphatase of regenerating liver (PRL) phosphatase [IC50 values of 173 nM for PRL-1, 277 nM for PRL-2, and 128 nM for PRL-3], and induces p130Cas cleavage and apoptosis with anticancer effects. |
| Targets&IC50 | PRL3:128 nM , PRL1:173 nM , PRL2:277 nM |
| In vitro | in soft agar, Thienopyridone shows significant inhibition of tumor cell anchorage-independent growth (EC50 of the Thienopyridone are 3.29 μM and 3.05 μM for RKO and HT-29 cells, respectively). Thienopyridone (1-75 μM; 24 hours; HeLa cells) treatment shows a dose-dependent down-regulation of total p130Cas in HeLa cells. Thienopyridone induces p130Cas and FAK cleavage leads to caspase-mediated cell apoptosis. the cleavage of PARP and caspase-8 induced by Thienopyridone. Thienopyridone (3.75-30 μM; 24 hours) significantly suppresses HUVEC migration but not proliferation. |
| Molecular Weight | 242.3 |
| Formula | C13H10N2OS |
| Cas No. | 1018454-97-1 |
| Smiles | Nc1c[nH]c(=O)c2cc(sc12)-c1ccccc1 |
| Relative Density. | 1.328 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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