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Anti-IGFBP-3 Antibody (3E206)

😃Good
Catalog No. TMAY-00819
Alias insulin-like growth factor binding protein 3

Anti-IGFBP-3 Antibody (3E206) is a Mouse antibody targeting IGFBP-3. Anti-IGFBP-3 Antibody (3E206) can be used in ELISA.

Anti-IGFBP-3 Antibody (3E206)

Anti-IGFBP-3 Antibody (3E206)

😃Good
Catalog No. TMAY-00819Alias insulin-like growth factor binding protein 3
Anti-IGFBP-3 Antibody (3E206) is a Mouse antibody targeting IGFBP-3. Anti-IGFBP-3 Antibody (3E206) can be used in ELISA.
Pack SizePriceAvailabilityQuantity
20 μL$92 7-10 days
100 μL$270 7-10 days
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Product Introduction

Bioactivity
Description
Anti-IGFBP-3 Antibody (3E206) is a Mouse antibody targeting IGFBP-3. Anti-IGFBP-3 Antibody (3E206) can be used in ELISA.
Aliasinsulin-like growth factor binding protein 3
Ig Type
Monoclonal Mouse IgG2a
Clone
3E206
Reactivity
Human
Application
ELISA
Recommended Dose
ELISA: 1:1000-1:2000
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionThis antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IGFBP3 (rh IGFBP3; TMPY-00835; NP_000589.2; Gly 28-Lys 291). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundThe Insulin-like Growth Factor (IGF) signaling system plays a central role in cellular growth, differentiation, and proliferation. IGFBP3 is the most abundant IGF binding protein in human serum and is a growth inhibitory, apoptosis-inducing molecule, capable of acting via IGF-dependent and IGF-independent mechanisms. It appears to function both by cell cycle blockade and the induction of apoptosis. IGFBP3 can be transported to the nucleus by an importin beta mediated mechanism, where it has been shown to interact with the retinoid X receptor alpha and possibly other nuclear elements. IGFBP3 antiproliferative signaling appears to require an active transforming growth factor-beta (TGF-beta) signaling pathway, and IGFBP3 stimulates phosphorylation of the TGF-beta signaling intermediates Smad2 and Smad3. IGFBP3 has IGF-independent roles in inhibiting cell proliferation in cancer cell lines. Nuclear transcription factor, retinoid X receptor (RXR)-alpha, and IGFBP3 functionally interact to reduce prostate tumor growth and prostate-specific antigen in vivo. Several clinical studies have proposed that individuals with IGFBP3 levels in the upper range of normal may have a decreased risk for certain common cancers. This includes evidence of a protective effect against breast cancer, prostate cancer, colorectal cancer, and lung cancer. Moreover, IGFBP3 inhibits insulin-stimulated glucose uptake into adipocytes independent of IGF.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Human IGFBP3 protein (TMPY-00835)
Antigen Species
Human
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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