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Retro-2 cycl

Name: Retro-2 cycl
Brand: TargetMol
SKU: T12711
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12711Cas No. 1429192-00-6

Alias RN 1-001

Retro-2 cycl is an antiviral agent and a selective inhibitor of retrograde protein trafficking mediated by syntaxin-5 at the interface. Retro-2 cycl inhibits JCPyV(IC50s: 54 μM) and HPV16 pseudovirus(IC50s: 160 μM).

Retro-2 cycl

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Purity: 99.89%

Catalog No. T12711Alias RN 1-001Cas No. 1429192-00-6

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$40	In Stock	In Stock
10 mg	$64	In Stock	In Stock
25 mg	$129	In Stock	In Stock
50 mg	$213	In Stock	In Stock
100 mg	$347	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.89%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Retro-2 cycl AI Summary

Retro-2 cycl exhibits multifaceted bioactivity. It shows significant cytoprotective activity against shiga toxin-induced cytotoxicity in human HeLa cells, with a 100% activity level and an EC50 value of 27300.0 nM. Additionally, it inhibits shiga toxin retrograde transport in these cells with a 36.9% inhibition rate. The compound also demonstrates antiviral properties, reducing viral infectivity by 57.5% against JC polyomavirus after pre-incubation with a concentration of 25 µM for 0.5 hours. Its IC50 values are 54000.0 nM for JC polyomavirus and 160000.0 nM for HPV16 pseudovirus. Furthermore, Retro-2 cycl inhibits Escherichia coli Stx1 interaction in HeLa cells, effectively reducing the stimulation of protein synthesis as indicated by radiolabelled-methionine incorporation with an EC50 of 27300.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Retro-2 cycl is an antiviral agent and a selective inhibitor of retrograde protein trafficking mediated by syntaxin-5 at the interface. Retro-2 cycl inhibits JCPyV(IC50s: 54 μM) and HPV16 pseudovirus(IC50s: 160 μM).
Targets&IC50	JCPyV:54 μM, HPV-16:160 μM
Synonyms	RN 1-001

Chemical Properties

Molecular Weight	320.41
Formula	C₁₉H₁₆N₂OS
Cas No.	1429192-00-6
Smiles	Cc1ccc(s1)C1Nc2ccccc2C(=O)N1c1ccccc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 0.1 mg/mL (insoluble)

DMSO: 45 mg/mL (140.45 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.24 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1210 mL	15.6050 mL	31.2100 mL	156.0501 mL
5 mM	0.6242 mL	3.1210 mL	6.2420 mL	31.2100 mL
10 mM	0.3121 mL	1.5605 mL	3.1210 mL	15.6050 mL
20 mM	0.1561 mL	0.7803 mL	1.5605 mL	7.8025 mL
50 mM	0.0624 mL	0.3121 mL	0.6242 mL	3.1210 mL
100 mM	0.0312 mL	0.1561 mL	0.3121 mL	1.5605 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc