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Casein kinase 1δ-IN-6

Name: Casein kinase 1δ-IN-6
Brand: TargetMol
SKU: T77500
Price: 71 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T77500Cas No. 1579991-01-7

Casein kinase 1δ-IN-6 is a potent and selective inhibitor of the protein kinase CK-1δ with an IC50 of 23 nM, demonstrating neuroprotective and anti-inflammatory activity in both in vitro and in vivo assays. Casein kinase 1δ-IN-6 can be used to study neurodegenerative diseases.

Casein kinase 1δ-IN-6

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Purity: 99.87%

Catalog No. T77500Cas No. 1579991-01-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$71	-	In Stock
5 mg	$178	-	In Stock
10 mg	$268	-	In Stock
25 mg	$467	-	In Stock
50 mg	$653	-	In Stock
100 mg	$918	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.87%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Casein kinase 1δ-IN-6 AI Summary

Casein kinase 1δ-IN-6 exhibits potent inhibition of human recombinant CK-1delta with an IC50 of 23.0 nM and achieves greater than 60% inhibition at a concentration of 10 µM, as indicated by the Kinase-Glo assay utilizing casein as a substrate. It also demonstrates high permeability with a PAMPA assay value of 11.2 µcm/s. Additionally, it shows neuroprotective properties in Drosophila melanogaster by suppressing human TDP-43-induced neurotoxicity, which results in an increased mean lifespan of 37.84 days at a 100 nM concentration..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Casein kinase 1δ-IN-6 is a potent and selective inhibitor of the protein kinase CK-1δ with an IC50 of 23 nM, demonstrating neuroprotective and anti-inflammatory activity in both in vitro and in vivo assays. Casein kinase 1δ-IN-6 can be used to study neurodegenerative diseases.
Targets&IC50	CK1δ:23 nM

Chemical Properties

Molecular Weight	370.78
Formula	C₁₆H₁₀ClF₃N₂OS
Cas No.	1579991-01-7
Smiles	N(C(CC1=CC(Cl)=CC=C1)=O)C=2SC=3C(N2)=CC=C(C(F)(F)F)C3
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (148.34 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6970 mL	13.4851 mL	26.9702 mL	134.8509 mL
5 mM	0.5394 mL	2.6970 mL	5.3940 mL	26.9702 mL
10 mM	0.2697 mL	1.3485 mL	2.6970 mL	13.4851 mL
20 mM	0.1349 mL	0.6743 mL	1.3485 mL	6.7425 mL
50 mM	0.0539 mL	0.2697 mL	0.5394 mL	2.6970 mL
100 mM	0.0270 mL	0.1349 mL	0.2697 mL	1.3485 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc