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Casein kinase 1δ-IN-6

🥰Excellent
Catalog No. T77500Cas No. 1579991-01-7

Casein kinase 1δ-IN-6 is a potent and selective inhibitor of the protein kinase CK-1δ with an IC50 of 23 nM, demonstrating neuroprotective and anti-inflammatory activity in both in vitro and in vivo assays. Casein kinase 1δ-IN-6 can be used to study neurodegenerative diseases.

Casein kinase 1δ-IN-6

Casein kinase 1δ-IN-6

🥰Excellent
Purity: 99%
Catalog No. T77500Cas No. 1579991-01-7
Casein kinase 1δ-IN-6 is a potent and selective inhibitor of the protein kinase CK-1δ with an IC50 of 23 nM, demonstrating neuroprotective and anti-inflammatory activity in both in vitro and in vivo assays. Casein kinase 1δ-IN-6 can be used to study neurodegenerative diseases.
Pack SizePriceAvailabilityQuantity
1 mg$129In Stock
2 mg$186In Stock
5 mg$297In Stock
10 mg$446In Stock
25 mg$778In Stock
50 mg$1,090In Stock
100 mg$1,530In Stock
500 mg$2,970In Stock
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Purity:99%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
Casein kinase 1δ-IN-6 is a potent and selective inhibitor of the protein kinase CK-1δ with an IC50 of 23 nM, demonstrating neuroprotective and anti-inflammatory activity in both in vitro and in vivo assays. Casein kinase 1δ-IN-6 can be used to study neurodegenerative diseases.
Targets&IC50
CK1δ:23 nM
Chemical Properties
Molecular Weight370.78
FormulaC16H10ClF3N2OS
Cas No.1579991-01-7
SmilesN(C(CC1=CC(Cl)=CC=C1)=O)C=2SC=3C(N2)=CC=C(C(F)(F)F)C3
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 55 mg/mL (148.34 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6970 mL13.4851 mL26.9702 mL134.8509 mL
5 mM0.5394 mL2.6970 mL5.3940 mL26.9702 mL
10 mM0.2697 mL1.3485 mL2.6970 mL13.4851 mL
20 mM0.1349 mL0.6743 mL1.3485 mL6.7425 mL
50 mM0.0539 mL0.2697 mL0.5394 mL2.6970 mL
100 mM0.0270 mL0.1349 mL0.2697 mL1.3485 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

CK1δCaseinkinase1δIN6CaseinKinaseCasein kinase 1δ-IN-6Casein kinase 1delta-IN-6Casein Kinase
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