Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Izuforant (JW1601) (Compound 24) has potent anti-inflammatory and anti-pruritic activities. Izuforant has a binding affinity for human serotonin 3 receptor (h5-HT3R) with an IC50 value of 9.1 μM. Izuforant is also an orally active antagonist of histamine H4 receptor (H4R) with an IC50 value of 36 nM against human H4R [1] [2].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | Izuforant (JW1601) (Compound 24) has potent anti-inflammatory and anti-pruritic activities. Izuforant has a binding affinity for human serotonin 3 receptor (h5-HT3R) with an IC50 value of 9.1 μM. Izuforant is also an orally active antagonist of histamine H4 receptor (H4R) with an IC50 value of 36 nM against human H4R [1] [2]. |
In vitro | Izuforant (JW1601) (Compound 24) demonstrates metabolic stability, evidenced by its clearance rates (CL h,int) of 3.05 mL/min/mg in mice and 1.33 mL/min/mg in humans, indicating its efficient metabolism across these species [1]. |
In vivo | Izuforant (JW1601) administered orally at a dosage of 50 mg/kg once, effectively mitigates histamine-and substance P-induced itching in mice, while a higher dose of 100 mg/kg given twice daily for three weeks successfully attenuates oxazolone-induced atopic dermatitis in mice, demonstrating a 51.2% inhibition rate. This is observed in studies involving female ICR and Balb/c mice specifically aged 8 weeks and 6 weeks respectively, weighing 20±3 g. Additionally, pharmacokinetic analysis in both ICR mice and SD rats, with doses respective to their species (50 mg/kg for mice, 10 mg/kg for rats), reveals the compound's absorption and elimination profiles, marked by its half-life, maximum concentration (Cmax), and area under the curve (AUCinf), thus indicating the compound's effective duration and exposure in the body. |
Molecular Weight | 334.17 |
Formula | C12H12BrN7 |
CAS No. | 1429374-83-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Izuforant 1429374-83-3 inhibitor inhibit