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Cinobufaginol
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Synonyms:
Catalog No. TN1501 Copy Product Info
Purity: 99.97%
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Cinobufaginol is a natural bufadienolide isolated from the secretions of the Chinese toad (Bufo bufo gargarizans). Cinobufaginol exhibits significant cytotoxicity against various tumor cell lines, with IC₅₀ values of 803 μM and 1.270 μM for the human nasopharyngeal carcinoma cell lines CNE-1 and CNE-2Z, respectively. In tests against various cancer cell lines, including A549 (lung cancer), HCT-116 (colon cancer), and SKOV3 (ovarian cancer), the IC₅₀ values for cinobufaginol were all below 2.17 μM.
Cas No. 6691-83-4
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $126 | - | In Stock | |
| 5 mg | $318 | - | In Stock | |
| 10 mg | $473 | - | In Stock | |
| 25 mg | $759 | - | In Stock | |
| 50 mg | $987 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.97%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Cinobufaginol is a natural bufadienolide isolated from the secretions of the Chinese toad (Bufo bufo gargarizans). Cinobufaginol exhibits significant cytotoxicity against various tumor cell lines, with IC₅₀ values of 803 μM and 1.270 μM for the human nasopharyngeal carcinoma cell lines CNE-1 and CNE-2Z, respectively. In tests against various cancer cell lines, including A549 (lung cancer), HCT-116 (colon cancer), and SKOV3 (ovarian cancer), the IC₅₀ values for cinobufaginol were all below 2.17 μM. |
| Molecular Weight | 458.55 |
| Formula | C26H34O7 |
| Cas No. | 6691-83-4 |
| Smiles | C[C@]12[C@]3([C@](O3)([C@H](OC(C)=O)[C@@H]1C=4C=CC(=O)OC4)[H])[C@]5([C@](CC2)([C@]6(CO)[C@](CC5)(C[C@@H](O)CC6)[H])[H])[H] |
| Relative Density. | no data available |
| Storage | Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (87.23 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
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Related Tags: Cinobufaginol chemical structure | Cinobufaginol formula | Cinobufaginol molecular weight
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