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Protein kinase inhibitor H-7

🥰Excellent
Catalog No. T60109Cas No. 84477-87-2
Alias 5-(2-methylpiperazine-1-sulfonyl)isoquinoline, 1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine

Protein kinase inhibitor H-7 (5-(2-methylpiperazine-1-sulfonyl)isoquinoline) is a potent inhibitor of protein kinase C (PKC) with a Ki of 6 μM. Protein kinase inhibitor H-7 is also a cyclic nucleotide dependent protein kinase inhibitor.

Protein kinase inhibitor H-7
Other Forms of Protein kinase inhibitor H-7:
Protein kinase inhibitor H-7 dihydrochlorideT22831108930-17-2
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Protein kinase inhibitor H-7

🥰Excellent
Purity: 99.91%
Catalog No. T60109Alias 5-(2-methylpiperazine-1-sulfonyl)isoquinoline, 1-(5-Isoquinolinylsulfonyl)-2-methylpiperazineCas No. 84477-87-2
Protein kinase inhibitor H-7 (5-(2-methylpiperazine-1-sulfonyl)isoquinoline) is a potent inhibitor of protein kinase C (PKC) with a Ki of 6 μM. Protein kinase inhibitor H-7 is also a cyclic nucleotide dependent protein kinase inhibitor.
Pack SizePriceAvailabilityQuantity
10 mg$52In Stock
25 mg$82In Stock
50 mg$117In Stock
100 mgPreferentialIn Stock
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Batch Information

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Purity:99.91%
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Product Introduction

Bioactivity
Description
Protein kinase inhibitor H-7 (5-(2-methylpiperazine-1-sulfonyl)isoquinoline) is a potent inhibitor of protein kinase C (PKC) with a Ki of 6 μM. Protein kinase inhibitor H-7 is also a cyclic nucleotide dependent protein kinase inhibitor.
Targets&IC50
PKC:6 μM (Ki)
Synonyms5-(2-methylpiperazine-1-sulfonyl)isoquinoline, 1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine
Chemical Properties
Molecular Weight291.37
FormulaC14H17N3O2S
Cas No.84477-87-2
SmilesCC1CNCCN1S(=O)(=O)c1cccc2cnccc12
Relative Density.no data available
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 90 mg/mL (308.9 mM), Sonication and heating to 60℃ are recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.4321 mL17.1603 mL34.3206 mL171.6031 mL
5 mM0.6864 mL3.4321 mL6.8641 mL34.3206 mL
10 mM0.3432 mL1.7160 mL3.4321 mL17.1603 mL
20 mM0.1716 mL0.8580 mL1.7160 mL8.5802 mL
50 mM0.0686 mL0.3432 mL0.6864 mL3.4321 mL
100 mM0.0343 mL0.1716 mL0.3432 mL1.7160 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Protein kinase inhibitor H-7PKC
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