Shopping Cart

Your shopping cart is currently empty

Kanamycin sulfate

Name: Kanamycin sulfate
Brand: TargetMol
SKU: T0793
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T0793Cas No. 25389-94-0

Alias Ophtalmokalixan, Kanamycin monosulfate, Kanamycin A monosulfate

Kanamycin sulfate (Kanamycin monosulfate) is an aminoglycoside antibiotic that interferes with protein synthesis by binding to the 70S ribosomal subunit of bacteria. Kanamycin sulfate exhibits antimicrobial activity against both Gram-positive and Gram-negative bacteria, as well as mycoplasmas.

Kanamycin sulfate

Copy Product Info

🥰Excellent

Purity: 99.96%

Catalog No. T0793Alias Ophtalmokalixan, Kanamycin monosulfate, Kanamycin A monosulfateCas No. 25389-94-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
200 mg	$41	In Stock	In Stock
1 mL x 10 mM (in H2O)	$50	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.96%

Color:White

Resource Download

COA

Product Introduction

Bioactivity

Description	Kanamycin sulfate (Kanamycin monosulfate) is an aminoglycoside antibiotic that interferes with protein synthesis by binding to the 70S ribosomal subunit of bacteria. Kanamycin sulfate exhibits antimicrobial activity against both Gram-positive and Gram-negative bacteria, as well as mycoplasmas.
Targets&IC50	various strains of mycobacteria:1-5 μg/mL (MIC), Kirchbergand:1 µg/mL (MIC)
In vitro	METHODS: Human cell lines HEK293, OVCAR8 and CA46 were treated with Kanamycin sulfate (0-1 mM) and cell viability was measured using the CCK-8 assay. RESULTS: Kanamycin showed no cytotoxic effects in any of the cell lines. [1] METHODS: Mycobacteria H37Rv, H2, H37RvR-PAS, Ravenel, Kirchbergand and BCG were treated with Kanamycin sulfate (0.1-100 µg/mL) for 2 weeks and tested for antibacterial activity. RESULTS: Kanamycin showed good antimicrobial activity against various Mycobacterium species with MICs of 1 µg/mL and 5 µg/mL for Kirchbergand strains, respectively. [2]
In vivo	METHODS: To detect ototoxicity, Kanamycin sulfate (800 mg/kg) was administered subcutaneously to C57BL/6J mice twice daily for fifteen days. RESULTS: Different ototoxic regimens were evaluated by ABR and DPOAE measurements before and after treatment. Sensory cell loss was quantified by counting hair cells in the cochlea. The study demonstrated that the Kanamycin ototoxicity regimen was safe, well tolerated, and detected early significant changes in hearing thresholds by DPOAE in a small group of mice. [3]
Synonyms	Ophtalmokalixan, Kanamycin monosulfate, Kanamycin A monosulfate

Chemical Properties

Molecular Weight	582.58
Formula	C₁₈H₃₈N₄O₁₅S
Cas No.	25389-94-0
Smiles	OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O
Relative Density.	1.3619 g/cm3 (Estimated)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 100 mg/mL (171.65 mM), Sonication is recommended.

DMSO: Insoluble

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.7165 mL	8.5825 mL	17.1650 mL	85.8251 mL
5 mM	0.3433 mL	1.7165 mL	3.4330 mL	17.1650 mL
10 mM	0.1717 mL	0.8583 mL	1.7165 mL	8.5825 mL
20 mM	0.0858 mL	0.4291 mL	0.8583 mL	4.2913 mL
50 mM	0.0343 mL	0.1717 mL	0.3433 mL	1.7165 mL
100 mM	0.0172 mL	0.0858 mL	0.1717 mL	0.8583 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc