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Anti-Phospho-EIF4G1 (Ser1231) Polyclonal Antibody
😃Good
Catalog No. TMAC-01279
Alias p-EIF4G1 (Ser1231), p-EIF4G1 (S1231), EIF4G1 (p-Ser1231), EIF4G1 (p-S1231)
Anti-Phospho-EIF4G1 (Ser1231) Polyclonal Antibody is a Rabbit antibody targeting Phospho-EIF4G1 (Ser1231). Anti-Phospho-EIF4G1 (Ser1231) Polyclonal Antibody can be used in IHC,WB.
Anti-Phospho-EIF4G1 (Ser1231) Polyclonal Antibody
Anti-Phospho-EIF4G1 (Ser1231) Polyclonal Antibody
😃Good
Catalog No. TMAC-01279Alias p-EIF4G1 (Ser1231), p-EIF4G1 (S1231), EIF4G1 (p-Ser1231), EIF4G1 (p-S1231)
Anti-Phospho-EIF4G1 (Ser1231) Polyclonal Antibody is a Rabbit antibody targeting Phospho-EIF4G1 (Ser1231). Anti-Phospho-EIF4G1 (Ser1231) Polyclonal Antibody can be used in IHC,WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $217 | 7-10 days | 7-10 days | |
| 100 μL | $317 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Phospho-EIF4G1 (Ser1231) Polyclonal Antibody is a Rabbit antibody targeting Phospho-EIF4G1 (Ser1231). Anti-Phospho-EIF4G1 (Ser1231) Polyclonal Antibody can be used in IHC,WB. |
| Synonyms | p-EIF4G1 (Ser1231), p-EIF4G1 (S1231), EIF4G1 (p-Ser1231), EIF4G1 (p-S1231) |
| Ig Type | IgG |
| Reactivity | Human |
| Verified Activity | 1. Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using eIF4G (phospho-Ser1231) Antibody TMAC-01279 (left) or the same antibody preincubated with blocking peptide (right). 2. Western blot analysis of extracts from HT29 cells untreated or treated with Anisomycin using eIF4G (phospho-Ser1231) Antibody TMAC-01279.   |
| Application | |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Construction | Polyclonal Antibody |
| Purification | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Appearance | Liquid |
| Formulation | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. Interacts with eIF3, mutually exclusive with EIF4A1 or EIFA2, EIF4E and through its N-terminus with PAPBC1. Interacts through its C-terminus with the serine/threonine kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding these enzymes in place to phosphorylate EIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. EIF4G1/EIF4G3 interacts with PABPC1 to bring about circularization of the mRNA. Rapamycin can attenuate insulin stimulation mediated by FKBPs. Interacts with EIF4E3. Interacts with MIF4GD. Interacts with rotavirus A NSP3; in this interaction, NSP3 takes the place of PABPC1 thereby inducing shutoff of host protein synthesis |
| Conjucates | Unconjugated |
| Others Formats | Phospho |
| Immunogen | Peptide sequence around phosphorylation site of serine 1231 (P-V-S(p)-P-L) derived from Human eIF4G |
| Antigen Species | human |
| Uniprot ID |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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